ING1: Wikis

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Inhibitor of growth family, member 1
Identifiers
Symbols ING1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
External IDs OMIM601566 MGI1349481 HomoloGene40119 GeneCards: ING1 Gene
RNA expression pattern
PBB GE ING1 209808 x at tn.png
PBB GE ING1 208415 x at tn.png
PBB GE ING1 210350 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3621 26356
Ensembl ENSG00000153487 ENSMUSG00000045969
UniProt Q9UK53 Q3ULE3
RefSeq (mRNA) NM_005537 XM_976418
RefSeq (protein) NP_005528 XP_981512
Location (UCSC) Chr 13:
110.16 - 110.17 Mb
Chr 8:
11.56 - 11.56 Mb
PubMed search [1] [2]

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3]

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Contents

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

Interactions

ING1 has been shown to interact with HDAC1,[4][5] DMAP1,[6] PCNA,[7] SIN3A,[5] SAP30,[5] P53,[8][9] SMARCC1,[5] CREB binding protein[4] and SMARCA4.[5]

References

  1. ^ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nat Genet 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021.  
  2. ^ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenet Cell Genet 76 (3-4): 176–8. PMID 9186514.  
  3. ^ a b "Entrez Gene: ING1 inhibitor of growth family, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3621.  
  4. ^ a b Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug. 2002). "Human ING1 proteins differentially regulate histone acetylation". J. Biol. Chem. (United States) 277 (33): 29832–9. doi:10.1074/jbc.M200197200. ISSN 0021-9258. PMID 12015309.  
  5. ^ a b c d e Kuzmichev, A; Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb. 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Mol. Cell. Biol. (United States) 22 (3): 835–48. ISSN 0270-7306. PMID 11784859.  
  6. ^ Xin, Huawei; Yoon Ho-Guen, Singh Prim B, Wong Jiemin, Qin Jun (Mar. 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". J. Biol. Chem. (United States) 279 (10): 9539–46. doi:10.1074/jbc.M311587200. ISSN 0021-9258. PMID 14665632.  
  7. ^ Scott, M; Bonnefin P, Vieyra D, Boisvert F M, Young D, Bazett-Jones D P, Riabowol K (Oct. 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". J. Cell. Sci. (England) 114 (Pt 19): 3455–62. ISSN 0021-9533. PMID 11682605.  
  8. ^ Leung, Ka Man; Po Lai See, Tsang Fan Cheung, Siu Wai Yi, Lau Anita, Ho Horace T B, Poon Randy Y C (Sep. 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Res. (United States) 62 (17): 4890–3. ISSN 0008-5472. PMID 12208736.  
  9. ^ Garkavtsev, I; Grigorian I A, Ossovskaya V S, Chernov M V, Chumakov P M, Gudkov A V (Jan. 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature (ENGLAND) 391 (6664): 295–8. doi:10.1038/34675. ISSN 0028-0836. PMID 9440684.  

Further reading

  • Campos EI, Chin MY, Kuo WH, Li G (2004). "Biological functions of the ING family tumor suppressors.". Cell. Mol. Life Sci. 61 (19-20): 2597–613. doi:10.1007/s00018-004-4199-4. PMID 15526165.  
  • Helbing CC, Veillette C, Riabowol K, et al. (1997). "A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis.". Cancer Res. 57 (7): 1255–8. PMID 9102209.  
  • Garkavtsev I, Riabowol K (1997). "Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor.". Mol. Cell. Biol. 17 (4): 2014–9. PMID 9121449.  
  • Zeremski M, Horrigan SK, Grigorian IA, et al. (1997). "Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34.". Somat. Cell Mol. Genet. 23 (3): 233–6. doi:10.1007/BF02721376. PMID 9330636.  
  • Garkavtsev I, Grigorian IA, Ossovskaya VS, et al. (1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control.". Nature 391 (6664): 295–8. doi:10.1038/34675. PMID 9440695.  
  • Shinoura N, Muramatsu Y, Nishimura M, et al. (1999). "Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas.". Cancer Res. 59 (21): 5521–8. PMID 10554029.  
  • Jäger D, Stockert E, Scanlan MJ, et al. (2000). "Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene.". Cancer Res. 59 (24): 6197–204. PMID 10626813.  
  • Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D (2000). "Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions.". Genes Chromosomes Cancer 27 (3): 319–22. doi:10.1002/(SICI)1098-2264(200003)27:3<319::AID-GCC13>3.0.CO;2-P. PMID 10679922.  
  • Tokunaga E, Maehara Y, Oki E, et al. (2000). "Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers.". Cancer Lett. 152 (1): 15–22. doi:10.1016/S0304-3835(99)00434-6. PMID 10754201.  
  • Baranova AV, Ivanov DV, Makeeva NV, et al. (2000). "[Genomic organization of the suppressor gene for tumor growth ING1]". Mol. Biol. (Mosk.) 34 (2): 263–9. PMID 10779953.  
  • Saito A, Furukawa T, Fukushige S, et al. (2000). "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.". J. Hum. Genet. 45 (3): 177–81. doi:10.1007/s100380050206. PMID 10807544.  
  • Gunduz M, Ouchida M, Fukushima K, et al. (2000). "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.". Cancer Res. 60 (12): 3143–6. PMID 10866301.  
  • Skowyra D, Zeremski M, Neznanov N, et al. (2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.". J. Biol. Chem. 276 (12): 8734–9. doi:10.1074/jbc.M007664200. PMID 11118440.  
  • Nagashima M, Shiseki M, Miura K, et al. (2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9671–6. doi:10.1073/pnas.161151798. PMID 11481424.  
  • Scott M, Bonnefin P, Vieyra D, et al. (2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis.". J. Cell. Sci. 114 (Pt 19): 3455–62. PMID 11682605.  
  • Kuzmichev A, Zhang Y, Erdjument-Bromage H, et al. (2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).". Mol. Cell. Biol. 22 (3): 835–48. PMID 11784859.  
  • Nouman GS, Angus B, Lunec J, et al. (2002). "Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues.". Hybrid. Hybridomics 21 (1): 1–10. doi:10.1089/15368590252917584. PMID 11991811.  
  • Bromidge T, Lynas C (2002). "Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies.". Leuk. Res. 26 (7): 631–5. doi:10.1016/S0145-2126(01)00185-0. PMID 12008079.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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