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Inhibitor of growth family, member 2

PDB rendering based on 1wes.
Available structures
1wes, 2g6q
Symbols ING2; ING1L; p33ING2
External IDs OMIM604215 MGI1916510 HomoloGene20388 GeneCards: ING2 Gene
RNA expression pattern
PBB GE ING2 205981 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3622 69260
Ensembl ENSG00000168556 ENSMUSG00000063049
UniProt Q9H160 Q4VAD7
RefSeq (mRNA) NM_001564 XM_992381
RefSeq (protein) NP_001555 XP_997475
Location (UCSC) Chr 4:
184.66 - 184.67 Mb
Chr 8:
49.17 - 49.17 Mb
PubMed search [1] [2]

Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2 gene.[1][2]

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.[2]


  1. ^ Shimada Y, Saito A, Suzuki M, Takahashi E, Horie M (Mar 1999). "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor". Cytogenet Cell Genet 83 (3-4): 232-5. PMID 10072587.  
  2. ^ a b "Entrez Gene: ING2 inhibitor of growth family, member 2".  

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Nagashima M, Shiseki M, Miura K, et al. (2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9671–6. doi:10.1073/pnas.161151798. PMID 11481424.  
  • Kuzmichev A, Zhang Y, Erdjument-Bromage H, et al. (2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).". Mol. Cell. Biol. 22 (3): 835–48. PMID 11784859.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gozani O, Karuman P, Jones DR, et al. (2003). "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.". Cell 114 (1): 99–111. doi:10.1016/S0092-8674(03)00480-X. PMID 12859901.  
  • Sironi E, Cerri A, Tomasini D, et al. (2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes.". J. Cutan. Pathol. 31 (4): 318–22. doi:10.1111/j.0303-6987.2004.0187.x. PMID 15005689.  
  • Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro.". Nucleic Acids Res. 32 (12): 3632–41. doi:10.1093/nar/gkh692. PMID 15243141.  
  • He GH, Helbing CC, Wagner MJ, et al. (2005). "Phylogenetic analysis of the ING family of PHD finger proteins.". Mol. Biol. Evol. 22 (1): 104–16. doi:10.1093/molbev/msh256. PMID 15356280.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Chin MY, Ng KC, Li G (2005). "The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells.". Exp. Cell Res. 304 (2): 531–43. doi:10.1016/j.yexcr.2004.11.023. PMID 15748897.  
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.  
  • Pedeux R, Sengupta S, Shen JC, et al. (2005). "ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation.". Mol. Cell. Biol. 25 (15): 6639–48. doi:10.1128/MCB.25.15.6639-6648.2005. PMID 16024799.  
  • Okano T, Gemma A, Hosoya Y, et al. (2006). "Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer.". Oncol. Rep. 15 (3): 545–9. PMID 16465410.  
  • Wang J, Chin MY, Li G (2006). "The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation.". Cancer Res. 66 (4): 1906–11. doi:10.1158/0008-5472.CAN-05-3444. PMID 16488987.  
  • Lu F, Dai DL, Martinka M, et al. (2006). "Nuclear ING2 expression is reduced in human cutaneous melanomas.". Br. J. Cancer 95 (1): 80–6. doi:10.1038/sj.bjc.6603205. PMID 16755297.  
  • Wang Y, Wang J, Li G (2006). "Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis.". FEBS Lett. 580 (16): 3787–93. doi:10.1016/j.febslet.2006.05.065. PMID 16782091.  
  • Huang W, Zhang H, Davrazou F, et al. (2007). "Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling.". J. Am. Chem. Soc. 129 (20): 6498–506. doi:10.1021/ja070195b. PMID 17469822.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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