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Inhibitor of growth family, member 4

PDB rendering based on 1wen.
Available structures
1wen, 1weu, 2jmq
Symbols ING4; MGC12557; my036; p29ING4
External IDs OMIM608524 MGI107307 HomoloGene22952 GeneCards: ING4 Gene
RNA expression pattern
PBB GE ING4 48825 at tn.png
PBB GE ING4 218234 at tn.png
More reference expression data
Species Human Mouse
Entrez 51147 28019
Ensembl ENSG00000111653 ENSMUSG00000030330
UniProt Q9UNL4 Q8C0D7
RefSeq (mRNA) NM_016162 NM_133345
RefSeq (protein) NP_057246 NP_579923
Location (UCSC) Chr 12:
6.63 - 6.64 Mb
Chr 6:
125.01 - 125.01 Mb
PubMed search [1] [2]

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.[1][2]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.[2]



ING4 has been shown to interact with EP300,[1] RELA[3] and P53.[1][4]


  1. ^ a b c Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res 63 (10): 2373–8. PMID 12750254.  
  2. ^ a b "Entrez Gene: ING4 inhibitor of growth family, member 4".  
  3. ^ Garkavtsev, Igor; Kozin Sergey V, Chernova Olga, Xu Lei, Winkler Frank, Brown Edward, Barnett Gene H, Jain Rakesh K (Mar. 2004). "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis". Nature (England) 428 (6980): 328–32. doi:10.1038/nature02329. PMID 15029197.  
  4. ^ Tsai, Kuo-Wang; Tseng Hsiao-Chun, Lin Wen-Chang (Oct. 2008). "Two wobble-splicing events affect ING4 protein subnuclear localization and degradation". Exp. Cell Res. (United States) 314 (17): 3130–41. doi:10.1016/j.yexcr.2008.08.002. PMID 18775696.  

Further reading

  • Ozer A, Bruick RK (2006). "Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4.". Cell Cycle 4 (9): 1153–6. PMID 16096374.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Garkavtsev I, Kozin SV, Chernova O, et al. (2004). "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.". Nature 428 (6980): 328–32. doi:10.1038/nature02329. PMID 15029197.  
  • Zhang X, Xu LS, Wang ZQ, et al. (2004). "ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells.". FEBS Lett. 570 (1-3): 7–12. doi:10.1016/j.febslet.2004.06.010. PMID 15251430.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kim S, Chin K, Gray JW, Bishop JM (2004). "A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer.". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16251–6. doi:10.1073/pnas.0407158101. PMID 15528276.  
  • Zhang X, Wang KS, Wang ZQ, et al. (2005). "Nuclear localization signal of ING4 plays a key role in its binding to p53.". Biochem. Biophys. Res. Commun. 331 (4): 1032–8. doi:10.1016/j.bbrc.2005.04.023. PMID 15882981.  
  • Ozer A, Wu LC, Bruick RK (2005). "The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7481–6. doi:10.1073/pnas.0502716102. PMID 15897452.  
  • Gunduz M, Nagatsuka H, Demircan K, et al. (2005). "Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas.". Gene 356: 109–17. doi:10.1016/j.gene.2005.02.014. PMID 15935570.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.". Mol. Cell 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.  
  • Unoki M, Shen JC, Zheng ZM, Harris CC (2006). "Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility.". J. Biol. Chem. 281 (45): 34677–86. doi:10.1074/jbc.M606296200. PMID 16973615.  
  • Raho G, Miranda C, Tamborini E, et al. (2007). "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene.". Oncogene 26 (36): 5247–57. doi:10.1038/sj.onc.1210335. PMID 17325660.  
  • Zhang X, Lin DH, Jin Y, et al. (2007). "Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation.". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9517–22. doi:10.1073/pnas.0703383104. PMID 17517644.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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