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Inhibin, alpha
Identifiers
Symbols INHA;
External IDs OMIM147380 MGI96569 HomoloGene1652 GeneCards: INHA Gene
RNA expression pattern
PBB GE INHA 210141 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3623 16322
Ensembl ENSG00000123999 ENSMUSG00000032968
UniProt P05111 Q6GTG7
RefSeq (mRNA) NM_002191 NM_010564
RefSeq (protein) NP_002182 NP_034694
Location (UCSC) Chr 2:
220.15 - 220.15 Mb
Chr 1:
75.39 - 75.39 Mb
PubMed search [1] [2]

Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.[1]

Contents

Function

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.[2]

See also

References

  1. ^ Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology 122 (4): 1701–2. PMID 3345731.  
  2. ^ "Entrez Gene: INHA inhibin, alpha". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3623.  

Further reading

  • Mellor SL, Richards MG, Pedersen JS, et al. (1998). "Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer.". J. Clin. Endocrinol. Metab. 83 (3): 969–75. doi:10.1210/jc.83.3.969. PMID 9506758.  
  • Munz B, Hübner G, Tretter Y, et al. (1999). "A novel role of activin in inflammation and repair.". J. Endocrinol. 161 (2): 187–93. doi:10.1677/joe.0.1610187. PMID 10320815.  
  • Welt C, Sidis Y, Keutmann H, Schneyer A (2002). "Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium.". Exp. Biol. Med. (Maywood) 227 (9): 724–52. PMID 12324653.  
  • Shav-Tal Y, Zipori D (2003). "The role of activin a in regulation of hemopoiesis.". Stem Cells 20 (6): 493–500. doi:10.1634/stemcells.20-6-493. PMID 12456957.  
  • Shao L, Frigon NL, Young AL, et al. (1992). "Effect of activin A on globin gene expression in purified human erythroid progenitors.". Blood 79 (3): 773–81. PMID 1310063.  
  • Vannelli GB, Barni T, Forti G, et al. (1992). "Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study.". Cell Tissue Res. 269 (2): 221–7. PMID 1423490.  
  • Matzuk MM, Finegold MJ, Su JG, et al. (1992). "Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.". Nature 360 (6402): 313–9. doi:10.1038/360313a0. PMID 1448148.  
  • Shimonaka M, Inouye S, Shimasaki S, Ling N (1991). "Follistatin binds to both activin and inhibin through the common subunit.". Endocrinology 128 (6): 3313–5. PMID 2036994.  
  • Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990). "Activin B: precursor sequences, genomic structure and in vitro activities.". Mol. Endocrinol. 3 (9): 1352–8. doi:10.1210/mend-3-9-1352. PMID 2575216.  
  • Barton DE, Yang-Feng TL, Mason AJ, et al. (1989). "Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice.". Genomics 5 (1): 91–9. doi:10.1016/0888-7543(89)90091-8. PMID 2767687.  
  • Lappöhn RE, Burger HG, Bouma J, et al. (1989). "Inhibin as a marker for granulosa-cell tumors.". N. Engl. J. Med. 321 (12): 790–3. PMID 2770810.  
  • Mayo KE, Cerelli GM, Spiess J, et al. (1986). "Inhibin A-subunit cDNAs from porcine ovary and human placenta.". Proc. Natl. Acad. Sci. U.S.A. 83 (16): 5849–53. doi:10.1073/pnas.83.16.5849. PMID 3016724.  
  • Ramasharma K, Li CH (1987). "Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes.". Proc. Natl. Acad. Sci. U.S.A. 84 (11): 3595–8. doi:10.1073/pnas.84.11.3595. PMID 3035540.  
  • Murata M, Eto Y, Shibai H, et al. (1988). "Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.". Proc. Natl. Acad. Sci. U.S.A. 85 (8): 2434–8. doi:10.1073/pnas.85.8.2434. PMID 3267209.  
  • Burger HG, Igarashi M (1988). "Inhibin: definition and nomenclature, including related substances.". Endocrinology 122 (4): 1701–2. PMID 3345731.  
  • Mason AJ, Niall HD, Seeburg PH (1986). "Structure of two human ovarian inhibins.". Biochem. Biophys. Res. Commun. 135 (3): 957–64. doi:10.1016/0006-291X(86)91021-1. PMID 3754442.  
  • Stewart AG, Milborrow HM, Ring JM, et al. (1986). "Human inhibin genes. Genomic characterisation and sequencing.". FEBS Lett. 206 (2): 329–34. doi:10.1016/0014-5793(86)81006-7. PMID 3758355.  
  • Xu J, McKeehan K, Matsuzaki K, McKeehan WL (1995). "Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism.". J. Biol. Chem. 270 (11): 6308–13. doi:10.1074/jbc.270.11.6308. PMID 7890768.  
  • Nishihara T, Okahashi N, Ueda N (1994). "Activin A induces apoptotic cell death.". Biochem. Biophys. Res. Commun. 197 (2): 985–91. doi:10.1006/bbrc.1993.2576. PMID 8267637.  
  • Mason AJ, Farnworth PG, Sullivan J (1997). "Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A.". Mol. Endocrinol. 10 (9): 1055–65. doi:10.1210/me.10.9.1055. PMID 8885240.  
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