The Full Wiki

IRF2: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Interferon regulatory factor 2

PDB rendering based on 1irf.
Available structures
1irf, 1irg, 2irf
Identifiers
Symbols IRF2; DKFZp686F0244; IRF-2
External IDs OMIM147576 MGI96591 HomoloGene1659 GeneCards: IRF2 Gene
RNA expression pattern
PBB GE IRF2 203275 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3660 16363
Ensembl ENSG00000168310 ENSMUSG00000031627
UniProt P14316 Q2TAX8
RefSeq (mRNA) NM_002199 NM_008391
RefSeq (protein) NP_002190 NP_032417
Location (UCSC) Chr 4:
185.55 - 185.63 Mb
Chr 8:
48.24 - 48.35 Mb
PubMed search [1] [2]

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.[1]

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.[2]

Contents

See also

Interactions

IRF2 has been shown to interact with BRD7,[3] EP300[4] and PCAF.[4][5]

References

  1. ^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (Sep 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell 58 (4): 729–39. PMID 2475256.  
  2. ^ "Entrez Gene: IRF2 interferon regulatory factor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3660.  
  3. ^ Staal, A; Enserink J M, Stein J L, Stein G S, van Wijnen A J (Nov. 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. (UNITED STATES) 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. ISSN 0021-9541. PMID 11025449.  
  4. ^ a b Masumi, A; Ozato K (Jun. 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. (United States) 276 (24): 20973–80. doi:10.1074/jbc.M101707200. ISSN 0021-9258. PMID 11304541.  
  5. ^ Masumi, A; Wang I M, Lefebvre B, Yang X J, Nakatani Y, Ozato K (Mar. 1999). "The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness". Mol. Cell. Biol. (UNITED STATES) 19 (3): 1810–20. ISSN 0270-7306. PMID 10022868.  

Further reading

  • Harada H, Taniguchi T, Tanaka N (1999). "The role of interferon regulatory factors in the interferon system and cell growth control.". Biochimie 80 (8-9): 641–50. doi:10.1016/S0300-9084(99)80017-0. PMID 9865486.  
  • Pitha PM, Au WC, Lowther W, et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth.". Biochimie 80 (8-9): 651–8. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487.  
  • Itoh S, Harada H, Fujita T, et al. (1989). "Sequence of a cDNA coding for human IRF-2.". Nucleic Acids Res. 17 (20): 8372. doi:10.1093/nar/17.20.8372. PMID 2813069.  
  • Harada H, Takahashi E, Itoh S, et al. (1994). "Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.". Mol. Cell. Biol. 14 (2): 1500–9. PMID 7507207.  
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.  
  • Sharf R, Azriel A, Lejbkowicz F, et al. (1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors.". J. Biol. Chem. 270 (22): 13063–9. doi:10.1074/jbc.270.22.13063. PMID 7768900.  
  • Cha Y, Deisseroth AB (1994). "Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region.". J. Biol. Chem. 269 (7): 5279–87. PMID 8106512.  
  • Harada H, Kitagawa M, Tanaka N, et al. (1993). "Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2.". Science 259 (5097): 971–4. doi:10.1126/science.8438157. PMID 8438157.  
  • Drew PD, Franzoso G, Carlson LM, et al. (1996). "Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells.". J. Neuroimmunol. 63 (2): 157–62. doi:10.1016/0165-5728(95)00140-9. PMID 8550813.  
  • Birnbaum MJ, van Zundert B, Vaughan PS, et al. (1997). "Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo.". J. Cell. Biochem. 66 (2): 175–83. doi:10.1002/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N. PMID 9213219.  
  • Masumi A, Wang IM, Lefebvre B, et al. (1999). "The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness.". Mol. Cell. Biol. 19 (3): 1810–20. PMID 10022868.  
  • Li W, Nagineni CN, Hooks JJ, et al. (1999). "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors.". Invest. Ophthalmol. Vis. Sci. 40 (5): 976–82. PMID 10102295.  
  • Whitney LW, Becker KG, Tresser NJ, et al. (1999). "Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays.". Ann. Neurol. 46 (3): 425–8. doi:10.1002/1531-8249(199909)46:3<425::AID-ANA22>3.0.CO;2-O. PMID 10482277.  
  • Mild GC, Schmahl GE, Shayan P, Niemeyer CM (2000). "Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia.". Leuk. Lymphoma 35 (5-6): 507–11. PMID 10609788.  
  • Staal A, Enserink JM, Stein JL, et al. (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2.". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449.  
  • Larrea E, Alberdi A, Castelruiz Y, et al. (2001). "Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5.". J. Viral Hepat. 8 (2): 103–10. doi:10.1046/j.1365-2893.2001.00273.x. PMID 11264730.  
  • Masumi A, Ozato K (2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment.". J. Biol. Chem. 276 (24): 20973–80. doi:10.1074/jbc.M101707200. PMID 11304541.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message