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Interferon regulatory factor 3

PDB rendering based on 1j2f.
Available structures
1j2f, 1qwt, 1t2k, 1zoq
Identifiers
Symbols IRF3;
External IDs OMIM603734 MGI1859179 HomoloGene1208 GeneCards: IRF3 Gene
RNA expression pattern
PBB GE IRF3 202621 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3661 54131
Ensembl ENSG00000126456 ENSMUSG00000003184
UniProt Q14653 O54726
RefSeq (mRNA) NM_001571 NM_016849
RefSeq (protein) NP_001562 NP_058545
Location (UCSC) Chr 19:
54.85 - 54.86 Mb
Chr 7:
44.87 - 44.87 Mb
PubMed search [1] [2]

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.[1]

It is a member of the interferon regulatory transcription factor (IRF) family.[1] IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.[2] This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.[3]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations


Contents

Interactions

IRF3 has been shown to interact with IRF7.[4]

References

  1. ^ a b Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y, Algarte M, Lin R (1999). "Triggering the interferon response: the role of IRF-3 transcription factor". J. Interferon Cytokine Res. 19 (1): 1–13. doi:10.1089/107999099314360. PMID 10048763.  
  2. ^ Yoneyama M, Suhara W, Fujita T (2002). "Control of IRF-3 activation by phosphorylation". J. Interferon Cytokine Res. 22 (1): 73–6. doi:10.1089/107999002753452674. PMID 11846977.  
  3. ^ "Entrez Gene: IRF3 interferon regulatory factor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3661.  
  4. ^ Au, W C; Yeow W S, Pitha P M (Feb. 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology (United States) 280 (2): 273–82. doi:10.1006/viro.2000.0782. ISSN 0042-6822. PMID 11162841.  

Further reading

  • Pitha PM, Au WC, Lowther W, et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth.". Biochimie 80 (8-9): 651–8. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487.  
  • Yoneyama M, Suhara W, Fujita T (2002). "Control of IRF-3 activation by phosphorylation.". J. Interferon Cytokine Res. 22 (1): 73–6. doi:10.1089/107999002753452674. PMID 11846977.  
  • Au WC, Moore PA, Lowther W, et al. (1996). "Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11657–61. doi:10.1073/pnas.92.25.11657. PMID 8524823.  
  • Yoneyama M, Suhara W, Fukuhara Y, et al. (1998). "Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.". Embo J. 17 (4): 1087–95. doi:10.1093/emboj/17.4.1087. PMID 9463386.  
  • Weaver BK, Kumar KP, Reich NC (1998). "Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.". Mol. Cell. Biol. 18 (3): 1359–68. PMID 9488451.  
  • Lin R, Heylbroeck C, Pitha PM, Hiscott J (1998). "Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.". Mol. Cell. Biol. 18 (5): 2986–96. PMID 9566918.  
  • Ronco LV, Karpova AY, Vidal M, Howley PM (1998). "Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity.". Genes Dev. 12 (13): 2061–72. doi:10.1101/gad.12.13.2061. PMID 9649509.  
  • Bellingham J, Gregory-Evans K, Gregory-Evans CY (1999). "Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.". Ann. Hum. Genet. 62 (Pt 3): 231–4. doi:10.1046/j.1469-1809.1998.6230231.x. PMID 9803267.  
  • Lowther WJ, Moore PA, Carter KC, Pitha PM (1999). "Cloning and functional analysis of the human IRF-3 promoter.". DNA Cell Biol. 18 (9): 685–92. doi:10.1089/104454999314962. PMID 10492399.  
  • Kim T, Kim TY, Song YH, et al. (1999). "Activation of interferon regulatory factor 3 in response to DNA-damaging agents.". J. Biol. Chem. 274 (43): 30686–9. doi:10.1074/jbc.274.43.30686. PMID 10521456.  
  • Kumar KP, McBride KM, Weaver BK, et al. (2000). "Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1.". Mol. Cell. Biol. 20 (11): 4159–68. doi:10.1128/MCB.20.11.4159-4168.2000. PMID 10805757.  
  • Suhara W, Yoneyama M, Iwamura T, et al. (2000). "Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300.". J. Biochem. 128 (2): 301–7. PMID 10920266.  
  • Servant MJ, ten Oever B, LePage C, et al. (2001). "Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3.". J. Biol. Chem. 276 (1): 355–63. doi:10.1074/jbc.. PMID 11035028.  
  • Smith EJ, Marié I, Prakash A, et al. (2001). "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.". J. Biol. Chem. 276 (12): 8951–7. doi:10.1074/jbc.. PMID 11124948.  
  • Au WC, Yeow WS, Pitha PM (2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3.". Virology 280 (2): 273–82. doi:10.1006/viro.2000.0782. PMID 11162841.  
  • Barnes BJ, Moore PA, Pitha PM (2001). "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.". J. Biol. Chem. 276 (26): 23382–90. doi:10.1074/jbc.. PMID 11303025.  
  • Mach CM, Hargrove BW, Kunkel GR (2002). "The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene.". J. Biol. Chem. 277 (7): 4853–8. doi:10.1074/jbc.. PMID 11724783.  
  • Morin P, Bragança J, Bandu MT, et al. (2002). "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription.". J. Mol. Biol. 316 (5): 1009–22. doi:10.1006/jmbi.2001.5401. PMID 11884139.  

External links

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