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Interferon regulatory factor 4

PDB rendering based on 2dll.
Available structures
Symbols IRF4; LSIRF; MUM1
External IDs OMIM601900 MGI1096873 HomoloGene1842 GeneCards: IRF4 Gene
RNA expression pattern
PBB GE IRF4 216986 s at tn.png
PBB GE IRF4 216987 at tn.png
More reference expression data
Species Human Mouse
Entrez 3662 16364
Ensembl ENSG00000137265 ENSMUSG00000021356
UniProt Q15306 Q5SUZ4
RefSeq (mRNA) NM_002460 NM_013674
RefSeq (protein) NP_002451 NP_038702
Location (UCSC) Chr 6:
0.34 - 0.36 Mb
Chr 13:
30.76 - 30.77 Mb
PubMed search [1] [2]

Interferon regulatory factor 4 is a protein that in humans is encoded by the IRF4 gene.[1][2][3] In melanocytic cells the IRF4 gene may be regulated by MITF[4].


See also


IRF4 has been shown to interact with STAT6,[5] NFATC2,[6] BCL6[5] and SPI1.[7][8]


  1. ^ Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics 37 (2): 229–33. doi:10.1006/geno.1996.0547. PMID 8921401.  
  2. ^ Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (Jun 2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". J Virol 82 (13): 6251–8. doi:10.1128/JVI.00163-08. PMID 18417578.  
  3. ^ "Entrez Gene: IRF4 interferon regulatory factor 4".  
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.  
  5. ^ a b Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. ISSN 0022-1007. PMID 10601358.  
  6. ^ Rengarajan, Jyothi; Mowen Kerri A, McBride Kathryn D, Smith Erica D, Singh Harinder, Glimcher Laurie H (Apr. 2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. (United States) 195 (8): 1003–12. ISSN 0022-1007. PMID 11956291.  
  7. ^ Brass, A L; Zhu A Q, Singh H (Feb. 1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. (ENGLAND) 18 (4): 977–91. doi:10.1093/emboj/18.4.977. ISSN 0261-4189. PMID 10022840.  
  8. ^ Escalante, Carlos R; Shen Leyi, Escalante Mary C, Brass Abraham L, Edwards Thomas A, Singh Harinder, Aggarwal Aneel K (Jul. 2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. (United States) 139 (1): 55–9. ISSN 1047-8477. PMID 12372320.  

Further reading

  • Mamane Y, Sharma S, Grandvaux N, et al. (2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis.". J. Interferon Cytokine Res. 22 (1): 135–43. doi:10.1089/107999002753452746. PMID 11846984.  
  • Yamagata T, Nishida J, Tanaka S, et al. (1996). "A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes.". Mol. Cell. Biol. 16 (4): 1283–94. PMID 8657101.  
  • Iida S, Rao PH, Butler M, et al. (1997). "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.". Nat. Genet. 17 (2): 226–30. doi:10.1038/ng1097-226. PMID 9326949.  
  • Brass AL, Zhu AQ, Singh H (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers.". Embo J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMID 10022840.  
  • Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.". J. Biol. Chem. 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196.  
  • Marecki S, Atchison ML, Fenton MJ (1999). "Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages.". J. Immunol. 163 (5): 2713–22. PMID 10453013.  
  • Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.". J. Exp. Med. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMID 10601358.  
  • Mamane Y, Sharma S, Petropoulos L, et al. (2000). "Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52.". Immunity 12 (2): 129–40. doi:10.1016/S1074-7613(00)80166-1. PMID 10714679.  
  • Gupta S, Anthony A, Pernis AB (2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins.". J. Immunol. 166 (10): 6104–11. PMID 11342629.  
  • Imaizumi Y, Kohno T, Yamada Y, et al. (2002). "Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia.". Jpn. J. Cancer Res. 92 (12): 1284–92. PMID 11749693.  
  • Rengarajan J, Mowen KA, McBride KD, et al. (2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.". J. Exp. Med. 195 (8): 1003–12. doi:10.1084/jem.20011128. PMID 11956291.  
  • Sharma S, Grandvaux N, Mamane Y, et al. (2002). "Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells.". J. Immunol. 169 (6): 3120–30. PMID 12218129.  
  • Escalante CR, Shen L, Escalante MC, et al. (2003). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex.". J. Struct. Biol. 139 (1): 55–9. doi:10.1016/S1047-8477(02)00514-2. PMID 12372320.  
  • Hu CM, Jang SY, Fanzo JC, Pernis AB (2003). "Modulation of T cell cytokine production by interferon regulatory factor-4.". J. Biol. Chem. 277 (51): 49238–46. doi:10.1074/jbc.M205895200. PMID 12374808.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Fanzo JC, Hu CM, Jang SY, Pernis AB (2003). "Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4).". J. Exp. Med. 197 (3): 303–14. doi:10.1084/jem.20020717. PMID 12566414.  
  • O'Reilly D, Quinn CM, El-Shanawany T, et al. (2003). "Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.". J. Biol. Chem. 278 (24): 21909–19. doi:10.1074/jbc.M212150200. PMID 12676954.  
  • Sundram U, Harvell JD, Rouse RV, Natkunam Y (2004). "Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA.". Mod. Pathol. 16 (8): 802–10. doi:10.1097/01.MP.0000081726.49886.CF. PMID 12920225.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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