The Full Wiki

IRF4: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Interferon regulatory factor 4

PDB rendering based on 2dll.
Available structures
2dll
Identifiers
Symbols IRF4; LSIRF; MUM1
External IDs OMIM601900 MGI1096873 HomoloGene1842 GeneCards: IRF4 Gene
RNA expression pattern
PBB GE IRF4 216986 s at tn.png
PBB GE IRF4 216987 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3662 16364
Ensembl ENSG00000137265 ENSMUSG00000021356
UniProt Q15306 Q5SUZ4
RefSeq (mRNA) NM_002460 NM_013674
RefSeq (protein) NP_002451 NP_038702
Location (UCSC) Chr 6:
0.34 - 0.36 Mb
Chr 13:
30.76 - 30.77 Mb
PubMed search [1] [2]

Interferon regulatory factor 4 is a protein that in humans is encoded by the IRF4 gene.[1][2][3] In melanocytic cells the IRF4 gene may be regulated by MITF[4].

Contents

See also

Interactions

IRF4 has been shown to interact with STAT6,[5] NFATC2,[6] BCL6[5] and SPI1.[7][8]

References

  1. ^ Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics 37 (2): 229–33. doi:10.1006/geno.1996.0547. PMID 8921401.  
  2. ^ Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (Jun 2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". J Virol 82 (13): 6251–8. doi:10.1128/JVI.00163-08. PMID 18417578.  
  3. ^ "Entrez Gene: IRF4 interferon regulatory factor 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3662.  
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.  
  5. ^ a b Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. ISSN 0022-1007. PMID 10601358.  
  6. ^ Rengarajan, Jyothi; Mowen Kerri A, McBride Kathryn D, Smith Erica D, Singh Harinder, Glimcher Laurie H (Apr. 2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. (United States) 195 (8): 1003–12. ISSN 0022-1007. PMID 11956291.  
  7. ^ Brass, A L; Zhu A Q, Singh H (Feb. 1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. (ENGLAND) 18 (4): 977–91. doi:10.1093/emboj/18.4.977. ISSN 0261-4189. PMID 10022840.  
  8. ^ Escalante, Carlos R; Shen Leyi, Escalante Mary C, Brass Abraham L, Edwards Thomas A, Singh Harinder, Aggarwal Aneel K (Jul. 2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. (United States) 139 (1): 55–9. ISSN 1047-8477. PMID 12372320.  

Further reading

  • Mamane Y, Sharma S, Grandvaux N, et al. (2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis.". J. Interferon Cytokine Res. 22 (1): 135–43. doi:10.1089/107999002753452746. PMID 11846984.  
  • Yamagata T, Nishida J, Tanaka S, et al. (1996). "A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes.". Mol. Cell. Biol. 16 (4): 1283–94. PMID 8657101.  
  • Iida S, Rao PH, Butler M, et al. (1997). "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.". Nat. Genet. 17 (2): 226–30. doi:10.1038/ng1097-226. PMID 9326949.  
  • Brass AL, Zhu AQ, Singh H (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers.". Embo J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMID 10022840.  
  • Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.". J. Biol. Chem. 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196.  
  • Marecki S, Atchison ML, Fenton MJ (1999). "Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages.". J. Immunol. 163 (5): 2713–22. PMID 10453013.  
  • Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.". J. Exp. Med. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMID 10601358.  
  • Mamane Y, Sharma S, Petropoulos L, et al. (2000). "Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52.". Immunity 12 (2): 129–40. doi:10.1016/S1074-7613(00)80166-1. PMID 10714679.  
  • Gupta S, Anthony A, Pernis AB (2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins.". J. Immunol. 166 (10): 6104–11. PMID 11342629.  
  • Imaizumi Y, Kohno T, Yamada Y, et al. (2002). "Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia.". Jpn. J. Cancer Res. 92 (12): 1284–92. PMID 11749693.  
  • Rengarajan J, Mowen KA, McBride KD, et al. (2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.". J. Exp. Med. 195 (8): 1003–12. doi:10.1084/jem.20011128. PMID 11956291.  
  • Sharma S, Grandvaux N, Mamane Y, et al. (2002). "Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells.". J. Immunol. 169 (6): 3120–30. PMID 12218129.  
  • Escalante CR, Shen L, Escalante MC, et al. (2003). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex.". J. Struct. Biol. 139 (1): 55–9. doi:10.1016/S1047-8477(02)00514-2. PMID 12372320.  
  • Hu CM, Jang SY, Fanzo JC, Pernis AB (2003). "Modulation of T cell cytokine production by interferon regulatory factor-4.". J. Biol. Chem. 277 (51): 49238–46. doi:10.1074/jbc.M205895200. PMID 12374808.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Fanzo JC, Hu CM, Jang SY, Pernis AB (2003). "Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4).". J. Exp. Med. 197 (3): 303–14. doi:10.1084/jem.20020717. PMID 12566414.  
  • O'Reilly D, Quinn CM, El-Shanawany T, et al. (2003). "Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.". J. Biol. Chem. 278 (24): 21909–19. doi:10.1074/jbc.M212150200. PMID 12676954.  
  • Sundram U, Harvell JD, Rouse RV, Natkunam Y (2004). "Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA.". Mod. Pathol. 16 (8): 802–10. doi:10.1097/01.MP.0000081726.49886.CF. PMID 12920225.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message