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Interferon regulatory factor 5
Symbols IRF5;
External IDs OMIM607218 MGI1350924 HomoloGene8088 GeneCards: IRF5 Gene
RNA expression pattern
PBB GE IRF5 205469 s at tn.png
PBB GE IRF5 205468 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3663 27056
Ensembl ENSG00000128604 ENSMUSG00000029771
UniProt Q13568 Q3U169
RefSeq (mRNA) NM_002200 NM_012057
RefSeq (protein) NP_002191 NP_036187
Location (UCSC) Chr 7:
128.37 - 128.38 Mb
Chr 6:
29.48 - 29.49 Mb
PubMed search [1] [2]

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene.[1]

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.[1]


See also


Further reading

  • Pitha PM, Au WC, Lowther W, et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth.". Biochimie 80 (8-9): 651–8. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487.  
  • Barnes B, Lubyova B, Pitha PM (2002). "On the role of IRF in host defense.". J. Interferon Cytokine Res. 22 (1): 59–71. doi:10.1089/107999002753452665. PMID 11846976.  
  • Barnes BJ, Moore PA, Pitha PM (2001). "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.". J. Biol. Chem. 276 (26): 23382–90. doi:10.1074/jbc.M101216200. PMID 11303025.  
  • Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein.". Mol. Cell. Biol. 22 (11): 3942–57. doi:10.1128/MCB.22.11.3942-3957.2002. PMID 11997525.  
  • Barnes BJ, Kellum MJ, Field AE, Pitha PM (2002). "Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes.". Mol. Cell. Biol. 22 (16): 5721–40. doi:10.1128/MCB.22.16.5721-5740.2002. PMID 12138184.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Barnes BJ, Field AE, Pitha-Rowe PM (2003). "Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes.". J. Biol. Chem. 278 (19): 16630–41. doi:10.1074/jbc.M212609200. PMID 12600985.  
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.  
  • Barnes BJ, Kellum MJ, Pinder KE, et al. (2003). "Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death.". Cancer Res. 63 (19): 6424–31. PMID 14559832.  
  • Barnes BJ, Richards J, Mancl M, et al. (2004). "Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection.". J. Biol. Chem. 279 (43): 45194–207. doi:10.1074/jbc.M400726200. PMID 15308637.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Lin R, Yang L, Arguello M, et al. (2005). "A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.". J. Biol. Chem. 280 (4): 3088–95. doi:10.1074/jbc.M408452200. PMID 15556946.  
  • Sigurdsson S, Nordmark G, Göring HH, et al. (2005). "Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.". Am. J. Hum. Genet. 76 (3): 528–37. doi:10.1086/428480. PMID 15657875.  
  • Takaoka A, Yanai H, Kondo S, et al. (2005). "Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.". Nature 434 (7030): 243–9. doi:10.1038/nature03308. PMID 15665823.  
  • Schoenemeyer A, Barnes BJ, Mancl ME, et al. (2005). "The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.". J. Biol. Chem. 280 (17): 17005–12. doi:10.1074/jbc.M412584200. PMID 15695821.  
  • Mancl ME, Hu G, Sangster-Guity N, et al. (2005). "Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function.". J. Biol. Chem. 280 (22): 21078–90. doi:10.1074/jbc.M500543200. PMID 15805103.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Graham RR, Kozyrev SV, Baechler EC, et al. (2006). "A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.". Nat. Genet. 38 (5): 550–5. doi:10.1038/ng1782. PMID 16642019.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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