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Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

PDB rendering based on 1txv.
Available structures
1txv, 1ty3, 1ty5, 1ty6, 1ty7, 1tye
Identifiers
Symbols ITGA2B; GTA; CD41; CD41B; GP2B; GPIIb; HPA3
External IDs OMIM607759 MGI96601 HomoloGene37304 GeneCards: ITGA2B Gene
RNA expression pattern
PBB GE ITGA2B 206493 at tn.png
PBB GE ITGA2B 206494 s at tn.png
PBB GE ITGA2B 216956 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3674 16399
Ensembl ENSG00000005961 ENSMUSG00000034664
UniProt P08514 Q3U3R7
RefSeq (mRNA) NM_000419 NM_010575
RefSeq (protein) NP_000410 NP_034705
Location (UCSC) Chr 17:
39.81 - 39.82 Mb
Chr 11:
102.27 - 102.29 Mb
PubMed search [1] [2]

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene.

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[1]

Contents

Interactions

ITGA2B has been shown to interact with AUP1[2] and CLNS1A.[3]

See also

References

  1. ^ "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3674.  
  2. ^ Kato, Atsushi; Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug. 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. (United States) 277 (32): 28934–41. doi:10.1074/jbc.M204340200. ISSN 0021-9258. PMID 12042322.  
  3. ^ Larkin, Deirdre; Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun. 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. (United States) 279 (26): 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326.  

Further reading

  • Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.  
  • Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3.". Curr. Opin. Hematol. 4 (5): 317–22. PMID 9288464.  
  • Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.  
  • Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization.". Am. J. Cardiol. 82 (8B): 36P–42P. doi:10.1016/S0002-9149(98)00662-6. PMID 9809890.  
  • Bennett JS (2001). "Platelet-fibrinogen interactions.". Ann. N. Y. Acad. Sci. 936: 340–54. PMID 11460491.  
  • Plow EF, Cierniewski CS, Xiao Z, et al. (2002). "AlphaIIbbeta3 and its antagonism at the new millennium.". Thromb. Haemost. 86 (1): 34–40. PMID 11487023.  
  • Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.  
  • Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.". Curr. Pharm. Des. 10 (14): 1567–76. doi:10.2174/1381612043384682. PMID 15134555.  
  • Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets.". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.  
  • Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3.". J. Clin. Invest. 115 (12): 3363–9. doi:10.1172/JCI26989. PMID 16322781.  
  • Ma YQ, Qin J, Plow EF (2007). "Platelet integrin alpha(IIb)beta(3): activation mechanisms.". J. Thromb. Haemost. 5 (7): 1345–52. doi:10.1111/j.1538-7836.2007.02537.x. PMID 17635696.  

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