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Integrin, alpha 6
Identifiers
Symbols ITGA6; CD49f; ITGA6B; VLA-6
External IDs OMIM147556 MGI96605 HomoloGene20091 GeneCards: ITGA6 Gene
RNA expression pattern
PBB GE ITGA6 201656 at tn.png
PBB GE ITGA6 215177 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3655 16403
Ensembl ENSG00000091409 ENSMUSG00000027111
UniProt P23229 Q3TWK2
RefSeq (mRNA) NM_000210 NM_008397
RefSeq (protein) NP_000201 NP_032423
Location (UCSC) Chr 2:
173 - 173.08 Mb
Chr 2:
71.59 - 71.66 Mb
PubMed search [1] [2]

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[1]

Contents

Interactions

ITGA6 has been shown to interact with TSPAN4[2] and GIPC1.[3]

See also

References

  1. ^ "Entrez Gene: ITGA6 integrin, alpha 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655.  
  2. ^ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (Nov. 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. ISSN 0021-9258. PMID 9360996.  
  3. ^ Tani, T T; Mercurio A M (Sep. 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.  

Further reading

  • Lipscomb EA, Mercurio AM (2006). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.". Cancer Metastasis Rev. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729.  

External links

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