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Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
Available structures
1jv2, 1l5g, 1m1x, 1u8c
Symbols ITGAV; CD51; MSK8; VNRA
External IDs OMIM193210 MGI96608 HomoloGene20510 GeneCards: ITGAV Gene
RNA expression pattern
PBB GE ITGAV 202351 at tn.png
More reference expression data
Species Human Mouse
Entrez 3685 16410
Ensembl ENSG00000138448 ENSMUSG00000027087
UniProt P06756 Q3U4C8
RefSeq (mRNA) NM_002210 NM_008402
RefSeq (protein) NP_002201 NP_032428
Location (UCSC) Chr 2:
187.16 - 187.25 Mb
Chr 2:
83.53 - 83.6 Mb
PubMed search [1] [2]

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.[1]

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[2]


See also


Further reading

  • Horton MA (1997). "The alpha v beta 3 integrin "vitronectin receptor".". Int. J. Biochem. Cell Biol. 29 (5): 721–5. PMID 9251239.  
  • Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.  
  • Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.  
  • Cooper CR, Chay CH, Pienta KJ (2002). "The role of alpha(v)beta(3) in prostate cancer progression.". Neoplasia 4 (3): 191–4. doi:10.1038/sj/neo/7900224. PMID 11988838.  
  • Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730.  

External links



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