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Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
Available structures
1jv2, 1l5g, 1m1x, 1u8c
Identifiers
Symbols ITGAV; CD51; MSK8; VNRA
External IDs OMIM193210 MGI96608 HomoloGene20510 GeneCards: ITGAV Gene
RNA expression pattern
PBB GE ITGAV 202351 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3685 16410
Ensembl ENSG00000138448 ENSMUSG00000027087
UniProt P06756 Q3U4C8
RefSeq (mRNA) NM_002210 NM_008402
RefSeq (protein) NP_002201 NP_032428
Location (UCSC) Chr 2:
187.16 - 187.25 Mb
Chr 2:
83.53 - 83.6 Mb
PubMed search [1] [2]

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.[1]

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[2]

Contents

See also

References

Further reading

  • Horton MA (1997). "The alpha v beta 3 integrin "vitronectin receptor".". Int. J. Biochem. Cell Biol. 29 (5): 721–5. PMID 9251239.  
  • Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.  
  • Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.  
  • Cooper CR, Chay CH, Pienta KJ (2002). "The role of alpha(v)beta(3) in prostate cancer progression.". Neoplasia 4 (3): 191–4. doi:10.1038/sj/neo/7900224. PMID 11988838.  
  • Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730.  

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