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ITGB3BP: Wikis


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Integrin beta 3 binding protein (beta3-endonexin)
Symbols ITGB3BP; CENP-R; CENPR; HSU37139; NRIF3; TAP20
External IDs OMIM605494 MGI1914983 HomoloGene8617 GeneCards: ITGB3BP Gene
RNA expression pattern
PBB GE ITGB3BP 205176 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23421 67733
Ensembl ENSG00000142856 ENSMUSG00000028549
UniProt Q13352 Q9CQ82
RefSeq (mRNA) NM_014288 NM_026348
RefSeq (protein) NP_055103 NP_080624
Location (UCSC) Chr 1:
63.68 - 63.76 Mb
Chr 4:
99.26 - 99.43 Mb
PubMed search [1] [2]

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.[1][2][3]


ITGB3BP has been shown to interact with Retinoid X receptor gamma,[4] Cyclin A2,[5] NFKB1,[6] Retinoid X receptor alpha,[2] Thyroid hormone receptor alpha[4][2] and CD61.[7][1]


  1. ^ a b Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH (Dec 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J Cell Biol 131 (3): 807–16. PMID 7593198.  
  2. ^ a b c Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (Feb 2000). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Mol Cell Biol 19 (10): 7191–202. PMID 10490654.  
  3. ^ "Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)".  
  4. ^ a b Li, D; Wang F, Samuels H H (Dec. 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMID 11713274.  
  5. ^ Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (Jan. 2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase". Biochem. Biophys. Res. Commun. (UNITED STATES) 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. ISSN 0006-291X. PMID 10673397.  
  6. ^ Besta, Felicitas; Massberg Steffen, Brand Korbinian, Müller Elke, Page Sharon, Grüner Sabine, Lorenz Michael, Sadoul Karin, Kolanus Waldemar, Lengyel Ernst, Gawaz Meinrad (Oct. 2002). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell. Sci. (England) 115 (Pt 20): 3879–88. ISSN 0021-9533. PMID 12244126.  
  7. ^ Fujimoto, Tetsuro-Takahiro; Katsutani Shinya, Shimomura Takeshi, Fujimura Kingo (Jan. 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. (United States) 105 (1): 63–70. ISSN 0049-3848. PMID 11864709.  

Further reading

  • Kashiwagi H, Schwartz MA, Eigenthaler M, et al. (1997). "Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail.". J. Cell Biol. 137 (6): 1433–43. doi:10.1083/jcb.137.6.1433. PMID 9182673.  
  • Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein.". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMID 10579726.  
  • Ohtoshi A, Maeda T, Higashi H, et al. (2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase.". Biochem. Biophys. Res. Commun. 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. PMID 10673397.  
  • Li D, Wang F, Samuels HH (2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation.". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMID 11713274.  
  • Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (2002). "Novel alternatively spliced form of beta(3)-endonexin.". Thromb. Res. 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. PMID 11864709.  
  • Besta F, Massberg S, Brand K, et al. (2003). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.". J. Cell. Sci. 115 (Pt 20): 3879–88. doi:10.1242/jcs.00081. PMID 12244126.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Li D, Das S, Yamada T, Samuels HH (2004). "The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.". Mol. Cell. Biol. 24 (9): 3838–48. doi:10.1128/MCB.24.9.3838-3848.2004. PMID 15082778.  
  • Talukder AH, Gururaj A, Mishra SK, et al. (2004). "Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.". Mol. Cell. Biol. 24 (15): 6581–91. doi:10.1128/MCB.24.15.6581-6591.2004. PMID 15254226.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex.". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.  
  • Okada M, Cheeseman IM, Hori T, et al. (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.". Nat. Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  


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