The Full Wiki

More info on ITPR3

ITPR3: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
inositol 1,4,5-trisphosphate receptor, type 3
Identifiers
Symbols ITPR3; IP3R; IP3R3; FLJ36205
External IDs OMIM147267 MGI96624 HomoloGene1675 GeneCards: ITPR3 Gene
Orthologs
Species Human Mouse
Entrez 3710 16440
Ensembl ENSG00000096433 ENSMUSG00000042644
UniProt Q14573 P70227
RefSeq (mRNA) NM_002224 NM_080553
RefSeq (protein) NP_002215 NP_542120
Location (UCSC) Chr 6:
33.7 - 33.77 Mb
Chr 17:
27.19 - 27.26 Mb
PubMed search [1] [2]

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.[1] The protein encoded by this gene is a both a receptor for inositol triphosphate and a calcium channel.[2]

Contents

See also

References

  1. ^ "Entrez Gene: inositol 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3710.  
  2. ^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels 2 (1): 9–22. PMID 8081734.  

Further reading

  • Kline CF, Cunha SR, Lowe JS, et al. (2008). "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor.". J. Cell. Biochem. 104 (4): 1244-53. doi:10.1002/jcb.21704. PMID 18275062.  
  • Oishi T, Iida A, Otsubo S, et al. (2008). "A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population.". J. Hum. Genet. 53 (2): 151-62. doi:10.1007/s10038-007-0233-3. PMID 18219441.  
  • Hirose M, Stuyvers B, Dun W, et al. (2008). "Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.". J. Mol. Cell. Cardiol. 45 (2): 176-84. doi:10.1016/j.yjmcc.2008.05.008. PMID 18586264.  
  • Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.". Mod Rheumatol 17 (2): 137-43. doi:10.1007/s10165-006-0555-6. PMID 17437169.  
  • Tang TS, Guo C, Wang H, et al. (2009). "Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model.". J. Neurosci. 29 (5): 1257-66. doi:10.1523/JNEUROSCI.4411-08.2009. PMID 19193873.  
  • Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008). "IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program.". J. Immunol. 181 (12): 8315-22. PMID 19050248.  
  • Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). "Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.". J. Biol. Chem. 280 (13): 12908-16. doi:10.1074/jbc.M410013200. PMID 15623527.  
  • Kasri NN, Holmes AM, Bultynck G, et al. (2004). "Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.". EMBO J. 23 (2): 312-21. doi:10.1038/sj.emboj.7600037. PMID 14685260.  
  • Hattori M, Suzuki AZ, Higo T, et al. (2004). "Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.". J. Biol. Chem. 279 (12): 11967-75. doi:10.1074/jbc.M311456200. PMID 14707143.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Roach JC, Deutsch K, Li S, et al. (2006). "Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden.". Am. J. Hum. Genet. 79 (4): 614-27. doi:10.1086/507876. PMID 16960798.  
  • Tojyo Y, Morita T, Nezu A, Tanimura A (2008). "The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca(2+) store.". J. Pharmacol. Sci. 107 (2): 138-50. PMID 18544901.  
  • Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation.". Exp. Cell Res. 295 (1): 102-18. doi:10.1016/j.yexcr.2003.12.025. PMID 15051494.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.  
  • Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection.". J. Neurosci. 28 (17): 4293-4. doi:10.1523/JNEUROSCI.0644-08.2008. PMID 18434505.  
  • Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II.". Genes Immun. 9 (3): 264-6. doi:10.1038/gene.2008.12. PMID 18340361.  
  • Wu Z, Bowen WD (2008). "Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells.". J. Biol. Chem. 283 (42): 28198-215. doi:10.1074/jbc.M802099200. PMID 18539593.  
  • Martínez-Gómez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.". Neuroreport 18 (5): 447-50. doi:10.1097/WNR.0b013e32805868a6. PMID 17496801.  
  • Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). "IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.". J. Biol. Chem. 283 (46): 31284-8. doi:10.1074/jbc.C800184200. PMID 18826956.  
  • Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009). "Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.". Am. J. Physiol., Cell Physiol. 296 (3): C403-13. doi:10.1152/ajpcell.00470.2008. PMID 19052258.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message