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inositol 1,4,5-trisphosphate receptor, type 3
Symbols ITPR3; IP3R; IP3R3; FLJ36205
External IDs OMIM147267 MGI96624 HomoloGene1675 GeneCards: ITPR3 Gene
Species Human Mouse
Entrez 3710 16440
Ensembl ENSG00000096433 ENSMUSG00000042644
UniProt Q14573 P70227
RefSeq (mRNA) NM_002224 NM_080553
RefSeq (protein) NP_002215 NP_542120
Location (UCSC) Chr 6:
33.7 - 33.77 Mb
Chr 17:
27.19 - 27.26 Mb
PubMed search [1] [2]

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.[1] The protein encoded by this gene is a both a receptor for inositol triphosphate and a calcium channel.[2]


See also


  1. ^ "Entrez Gene: inositol 1".  
  2. ^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels 2 (1): 9–22. PMID 8081734.  

Further reading

  • Kline CF, Cunha SR, Lowe JS, et al. (2008). "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor.". J. Cell. Biochem. 104 (4): 1244-53. doi:10.1002/jcb.21704. PMID 18275062.  
  • Oishi T, Iida A, Otsubo S, et al. (2008). "A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population.". J. Hum. Genet. 53 (2): 151-62. doi:10.1007/s10038-007-0233-3. PMID 18219441.  
  • Hirose M, Stuyvers B, Dun W, et al. (2008). "Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.". J. Mol. Cell. Cardiol. 45 (2): 176-84. doi:10.1016/j.yjmcc.2008.05.008. PMID 18586264.  
  • Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.". Mod Rheumatol 17 (2): 137-43. doi:10.1007/s10165-006-0555-6. PMID 17437169.  
  • Tang TS, Guo C, Wang H, et al. (2009). "Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model.". J. Neurosci. 29 (5): 1257-66. doi:10.1523/JNEUROSCI.4411-08.2009. PMID 19193873.  
  • Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008). "IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program.". J. Immunol. 181 (12): 8315-22. PMID 19050248.  
  • Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). "Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.". J. Biol. Chem. 280 (13): 12908-16. doi:10.1074/jbc.M410013200. PMID 15623527.  
  • Kasri NN, Holmes AM, Bultynck G, et al. (2004). "Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.". EMBO J. 23 (2): 312-21. doi:10.1038/sj.emboj.7600037. PMID 14685260.  
  • Hattori M, Suzuki AZ, Higo T, et al. (2004). "Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.". J. Biol. Chem. 279 (12): 11967-75. doi:10.1074/jbc.M311456200. PMID 14707143.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Roach JC, Deutsch K, Li S, et al. (2006). "Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden.". Am. J. Hum. Genet. 79 (4): 614-27. doi:10.1086/507876. PMID 16960798.  
  • Tojyo Y, Morita T, Nezu A, Tanimura A (2008). "The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca(2+) store.". J. Pharmacol. Sci. 107 (2): 138-50. PMID 18544901.  
  • Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation.". Exp. Cell Res. 295 (1): 102-18. doi:10.1016/j.yexcr.2003.12.025. PMID 15051494.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.  
  • Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection.". J. Neurosci. 28 (17): 4293-4. doi:10.1523/JNEUROSCI.0644-08.2008. PMID 18434505.  
  • Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II.". Genes Immun. 9 (3): 264-6. doi:10.1038/gene.2008.12. PMID 18340361.  
  • Wu Z, Bowen WD (2008). "Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells.". J. Biol. Chem. 283 (42): 28198-215. doi:10.1074/jbc.M802099200. PMID 18539593.  
  • Martínez-Gómez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.". Neuroreport 18 (5): 447-50. doi:10.1097/WNR.0b013e32805868a6. PMID 17496801.  
  • Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). "IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.". J. Biol. Chem. 283 (46): 31284-8. doi:10.1074/jbc.C800184200. PMID 18826956.  
  • Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009). "Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.". Am. J. Physiol., Cell Physiol. 296 (3): C403-13. doi:10.1152/ajpcell.00470.2008. PMID 19052258.  

External links



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