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Ibopamine
Systematic (IUPAC) name
5-[2-(methylamino)ethyl]-2-[(2-methylpropanoyl)oxy]phenyl 2-methylpropanoate
Identifiers
CAS number 66195-31-1
ATC code C01CA16 S01FB03
PubChem 68555
Chemical data
Formula C 17H25NO4  
Mol. mass 307.385 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Ibopamine is a sympathomimetic used in ophthalmology.[1] It induces mydriasis.[2] It also has been investigated for use in the treatment of congestive heart failure.[3]

It acts on D1[4][5] and α receptors as a agonist. [6]

See also

References

  1. ^ Magacho L, Costa ML, Dessimoni A, de Avila MP (2006). "Comparison between the 1% and 2% ibopamine provocative test in primary open-angle glaucoma patients: sensitivity, specificity and tolerability". Arq Bras Oftalmol 69 (5): 695–9. doi:10.1590/S0004-27492006000500015. PMID 17187138. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000500015&lng=en&nrm=iso&tlng=en.  
  2. ^ Marchini G, Babighian S, Tosi R, Perfetti S, Bonomi L (June 2001). "Effects of 2% ibopamine on pupil, refraction, anterior segment anatomy and intraocular pressure". J Ocul Pharmacol Ther 17 (3): 215–23. doi:10.1089/108076801750295254. PMID 11436942.  
  3. ^ van Veldhuisen DJ, Man in 't Veld AJ, Dunselman PH, et al. (November 1993). "Double-blind placebo-controlled study of ibopamine and digoxin in patients with mild to moderate heart failure: results of the Dutch Ibopamine Multicenter Trial (DIMT)". J. Am. Coll. Cardiol. 22 (6): 1564–73. PMID 7901256.  
  4. ^ Metra M, Missale C, Spano PF, Cas LD (May 1995). "Dopaminergic drugs in congestive heart failure: hemodynamic and neuroendocrine responses to ibopamine, dopamine, and dihydroergotoxine". J. Cardiovasc. Pharmacol. 25 (5): 732–40. PMID 7630152.  
  5. ^ Lieverse AG, Girbes AR, Van Veldhuisen DJ, et al. (July 1995). "The effects of ibopamine on glomerular filtration rate and plasma norepinephrine remain preserved during prolonged treatment in patients with congestive heart failure". Eur. Heart J. 16 (7): 937–42. PMID 7498209. http://eurheartj.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=7498209.  
  6. ^ "IngentaConnect Ibopamine Stimulates -Adrenergic Receptors and D1 Dopaminergic Re...". http://www.ingentaconnect.com/content/ben/cdth/2007/00000002/00000002/art00006.  
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