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Classification and external resources
ICD-10 Q80.
ICD-9 757.1
DiseasesDB 6646
MeSH D007057

Ichthyosis (plural ichthyoses) is a heterogeneous family of at least 28[1], generalized, mostly genetic skin disorders. All types of ichthyosis have dry, thickened, scaly or flaky skin.[1] In many types the skin is said to resemble the scales on a fish; the word ichthyosis comes from the Ancient Greek ιχθύς (ichthys), meaning "fish."[2] The severity of symptoms can vary enormously, from the mildest types such as ichthyosis vulgaris which may be mistaken for normal dry skin up to life-threatening conditions such as harlequin type ichthyosis. The most common type of ichthyosis is ichthyosis vulgaris, accounting for more than 95% of cases.[3]



There are many types of ichthyosis and an exact diagnosis may be difficult. Types of ichthyosis are classified by their appearance and their genetic cause. Ichthyoses caused by the same gene can vary considerably in severity and symptoms. Some ichthyoses don't appear to fit exactly into any one type. Also different genes can produce ichthyosis with similar symptoms. The most common or well-known types are as follows:[4]


Genetic ichthyoses

Ichthyoses with additional characteristics

Non-genetic ichthyosis


A physician often can diagnose ichthyosis by looking at the skin. A family history is very useful. In some cases, a skin biopsy is done to help to confirm the diagnosis. In a biopsy, a small piece of skin is removed and examined under a microscope. In some instances, genetic testing may be helpful in making a diagnosis.

Ichthyosis is not more or less common in any ethnic group. As of now, there is no way to prevent ichthyosis since it is often of a genetic nature.


Treatments for ichthyosis often take the form of topical application of creams and emollient oils, in an attempt to hydrate the skin. Retinoids are also used for some conditions. Exposure to sunlight may improve or worsen the condition.

There can be ocular manifestations of ichthyosis, such as corneal and ocular surface diseases. Vascularizing keratitis, which is more commonly found in congenital keratitis-ichythosis-deafness (KID), may worsen with isotretinoin therapy.

Ichthyosis in animals

Ichthyosis or ichthyosis-like diseases exist for several types of animals, including cattle, chickens, llamas, mice, and dogs.[5] Ichthyosis of varying severity is well-documented in some popular breeds of domestic dogs. The most common breeds to have ichthyosis are Golden retrievers, American bulldogs, Jack Russell terriers, and Cairn terriers.[6]

See also


  1. ^ a b FAQ, Foundation for Ichthyosis & Related Skin Types (F.I.R.S.T)
  2. ^ Ichthyosis, John Hopkins Health Information Library
  3. ^ Okulicz JF, Schwartz RA (2003). "Hereditary and acquired ichthyosis vulgaris". International Journal of Dermatology 42 (2): 95–8. doi:10.1046/j.1365-4362.2003.01308.x. PMID 12708996.  
  4. ^ Types of Ichthyosis, Foundation for Ichthyosis & Related Skin Types (F.I.R.S.T)
  5. ^ Sundberg, John P., Handbook of Mouse Mutations with Skin and Hair Abnormalities, Page 333, Published by CRC Press, 1994, ISBN 0849383722
  6. ^ Gross, Thelma Lee, Veterinary Dermatopathology, Page 174-179, Published by Blackwell Publishing, 2004, ISBN 0632064528

External links

1911 encyclopedia

Up to date as of January 14, 2010
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From LoveToKnow 1911

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