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Immunophilins: Wikis


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In molecular biology, immunophilins are endogenous transmembrane peptidyl-prolyl isomerases that intraconvert between the cis and trans positions.

Immunophilins are targeted by immunosuppressive drugs such as rapamycin, ciclosporin, and tacrolimus. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. However, this isomerase activity appears to be unrelated to their ability to bind these drugs.

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