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Indometacin farnesil: Wikis


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Indometacin farnesil
Systematic (IUPAC) name
(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
CAS number 85801-02-1
ATC code  ?
PubChem 5282183
Chemical data
Formula C 34H40ClNO4  
Mol. mass 562.14 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism To indometacin
Half life 1.5 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral

Indometacin farnesil (INN) is a prodrug of the non-steroidal anti-inflammatory drug indometacin, designed to reduce the occurrence of side-effects by esterification of the carboxyl group on indometacin with farnesol. Indometacin farnesil was first approved in Japan in 1991, and is available in Japan and Indonesia, under the trade names Infree and Dialon respectively.

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