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Indoprofen: Wikis


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Systematic (IUPAC) name
phenyl]propanoic acid
CAS number 31842-01-0
ATC code M01AE10
PubChem 3718
Chemical data
Formula C 17H15NO3  
Mol. mass 281.306 g/mol
Pharmacokinetic data
Bioavailability High (rapid and complete absorption)
Metabolism Glucuronidation
Half life 2.3 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Withdrawn
Routes Oral

Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]


  1. ^ a b Frazin, Natalie (March 9, 2005). "Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy". United States National Institute of Neurological Disorders and Stroke. Retrieved 2007-10-06.  
  2. ^ Lunn MR, Root DE, Martino AM, et al. (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol 11 (11): 1489–93. doi:10.1016/j.chembiol.2004.08.024. PMID 15555999.  


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