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Interferon gamma receptor 1: Wikis


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Interferon gamma receptor 1

PDB rendering based on 1fg9.
Available structures
1fg9, 1fyh, 1jrh
Symbols IFNGR1; CD119; FLJ45734; IFNGR
External IDs OMIM107470 MGI107655 HomoloGene359 GeneCards: IFNGR1 Gene
RNA expression pattern
PBB GE IFNGR1 202727 s at tn.png
PBB GE IFNGR1 211676 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3459 15979
Ensembl ENSG00000027697 ENSMUSG00000020009
UniProt P15260 Q3TW49
RefSeq (mRNA) NM_000416 NM_010511
RefSeq (protein) NP_000407 NP_034641
Location (UCSC) Chr 6:
137.56 - 137.58 Mb
Chr 10:
19.28 - 19.3 Mb
PubMed search [1] [2]

Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a human gene.[1][2][3]



IFNGR1 encodes the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2 encodes the non-ligand-binding partner of the heterodimeric receptor.[1]


Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.[4][5]

See also


  1. ^ a b "Entrez Gene: IFNGR1 interferon gamma receptor 1".  
  2. ^ Novick D, Orchansky P, Revel M, Rubinstein M (June 1987). "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". J. Biol. Chem. 262 (18): 8483–7. PMID 2954953.  
  3. ^ Aguet M, Dembić Z, Merlin G (October 1988). "Molecular cloning and expression of the human interferon-gamma receptor". Cell 55 (2): 273–80. doi:10.1016/0092-8674(88)90050-5. PMID 2971451.  
  4. ^ Thiel, D J; le Du M H, Walter R L, D'Arcy A, Chène C, Fountoulakis M, Garotta G, Winkler F K, Ealick S E (Sep. 2000). "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex". Structure (ENGLAND) 8 (9): 927–36. ISSN 0969-2126. PMID 10986460.  
  5. ^ Kotenko, S V; Izotova L S, Pollack B P, Mariano T M, Donnelly R J, Muthukumaran G, Cook J R, Garotta G, Silvennoinen O, Ihle J N (Sep. 1995). "Interaction between the components of the interferon gamma receptor complex". J. Biol. Chem. (UNITED STATES) 270 (36): 20915–21. ISSN 0021-9258. PMID 7673114.  

Further reading

  • Samuel CE (2002). "Antiviral actions of interferons.". Clin. Microbiol. Rev. 14 (4): 778–809, table of contents. doi:10.1128/CMR.14.4.778-809.2001. PMID 11585785.  
  • van Loon AP, Ozmen L, Fountoulakis M, et al. (1991). "High-affinity receptor for interferon-gamma (IFN-gamma), a ubiquitous protein occurring in different molecular forms on human cells: blood monocytes and eleven different cell lines have the same IFN-gamma receptor protein.". J. Leukoc. Biol. 49 (5): 462–73. PMID 1826725.  
  • Le Coniat M, Alcaide-Loridan C, Fellous M, Berger R (1990). "Human interferon gamma receptor 1 (IFNGR1) gene maps to chromosome region 6q23-6q24.". Hum. Genet. 84 (1): 92–4. doi:10.1007/BF00210682. PMID 2532616.  
  • Novick D, Orchansky P, Revel M, Rubinstein M (1987). "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies.". J. Biol. Chem. 262 (18): 8483–7. PMID 2954953.  
  • Aguet M, Dembić Z, Merlin G (1988). "Molecular cloning and expression of the human interferon-gamma receptor.". Cell 55 (2): 273–80. doi:10.1016/0092-8674(88)90050-5. PMID 2971451.  
  • Szente BE, Subramaniam PS, Johnson HM (1996). "Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133).". J. Immunol. 155 (12): 5617–22. PMID 7499845.  
  • Igarashi K, Garotta G, Ozmen L, et al. (1994). "Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.". J. Biol. Chem. 269 (20): 14333–6. PMID 7514165.  
  • Walter MR, Windsor WT, Nagabhushan TL, et al. (1995). "Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.". Nature 376 (6537): 230–5. doi:10.1038/376230a0. PMID 7617032.  
  • Kotenko SV, Izotova LS, Pollack BP, et al. (1995). "Interaction between the components of the interferon gamma receptor complex.". J. Biol. Chem. 270 (36): 20915–21. doi:10.1074/jbc.270.36.20915. PMID 7673114.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Tjoelker LW, Seyfried CE, Eddy RL, et al. (1994). "Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5.". Biochemistry 33 (11): 3229–36. doi:10.1021/bi00177a013. PMID 8136357.  
  • Greenlund AC, Farrar MA, Viviano BL, Schreiber RD (1994). "Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).". Embo J. 13 (7): 1591–600. PMID 8156998.  
  • Stüber D, Friedlein A, Fountoulakis M, et al. (1993). "Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity.". Biochemistry 32 (9): 2423–30. doi:10.1021/bi00060a038. PMID 8443182.  
  • Dalton DK, Pitts-Meek S, Keshav S, et al. (1993). "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.". Science 259 (5102): 1739–42. doi:10.1126/science.8456300. PMID 8456300.  
  • Novelli F, Giovarelli M, Gentz R, et al. (1993). "Modulation of interferon-gamma receptor during human T lymphocyte alloactivation.". Eur. J. Immunol. 23 (6): 1226–31. doi:10.1002/eji.1830230605. PMID 8500521.  
  • Newport MJ, Huxley CM, Huston S, et al. (1997). "A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection.". N. Engl. J. Med. 335 (26): 1941–9. doi:10.1056/NEJM199612263352602. PMID 8960473.  
  • Jouanguy E, Altare F, Lamhamedi S, et al. (1997). "Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.". N. Engl. J. Med. 335 (26): 1956–61. doi:10.1056/NEJM199612263352604. PMID 8960475.  
  • Gerritsma JS, Gerritsen AF, De Ley M, et al. (1997). "Interferon-gamma induces biosynthesis of complement components C2, C4 and factor H by human proximal tubular epithelial cells.". Cytokine 9 (4): 276–83. doi:10.1006/cyto.1996.0164. PMID 9112336.  
  • Sogabe S, Stuart F, Henke C, et al. (1998). "Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex.". J. Mol. Biol. 273 (4): 882–97. doi:10.1006/jmbi.1997.1336. PMID 9367779.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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