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Interleukin-17 receptor: Wikis


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interleukin 17 receptor A
Symbol IL17RA
Alt. symbols IL17R, CDw217
Entrez 23765
HUGO 5985
OMIM 605461
RefSeq NM_014339
UniProt Q96F46
Other data
Locus Chr. 22 q11.1
interleukin 17 receptor B
Symbol IL17RB
Alt. symbols IL17BR
Entrez 55540
HUGO 18015
OMIM 605458
RefSeq NM_172234
UniProt Q9NRM6
Other data
Locus Chr. 3 p21.1
interleukin 17 receptor C
Symbol IL17RC
Alt. symbols IL17-RL
Entrez 84818
HUGO 18358
OMIM 610925
RefSeq NM_032732
UniProt Q8NAC3
Other data
Locus Chr. 3 p25.3
interleukin 17 receptor D
Symbol IL17RD
Alt. symbols SEF, IL17RLM, FLJ35755, IL-17RD
Entrez 54756
HUGO 17616
OMIM 606807
RefSeq NM_017563
UniProt Q8NFM7
Other data
Locus Chr. 3 p21.1
interleukin 17 receptor E
Symbol IL17RE
Alt. symbols FLJ23658
Entrez 132014
HUGO 18439
RefSeq NM_153480
UniProt Q8NFR9
Other data
Locus Chr. 3 p25.3
interleukin 17 receptor E-like
Symbol IL17REL
Entrez 400935
HUGO 33808
RefSeq NM_001001694
UniProt Q6ZVW7
Other data
Locus Chr. 22 q13.33

Interleukin-17 receptor (IL-17R) is a cytokine receptor which binds interleukin 17.[1] Functional IL-17R is a heteromeric complex consisting of at least IL17RA and IL17RC.[2]

A number of additional variants exist including IL17RB,[3] which binds preferentially IL17B and IL17E.[4][5]


  1. ^ Yao Z, Spriggs MK, Derry JM, Strockbine L, Park LS, VandenBos T, Zappone JD, Painter SL, Armitage RJ (1997). "Molecular characterization of the human interleukin (IL)-17 receptor". Cytokine 9 (11): 794–800. doi:10.1006/cyto.1997.0240. PMID 9367539.  
  2. ^ Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J (2006). "Cutting edge: interleukin 17 signals through a heteromeric receptor complex". J. Immunol. 177 (1): 36–9. PMID 16785495.  
  3. ^ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD (2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801.  
  4. ^ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (2000). "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity". J. Biol. Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.  
  5. ^ Lee J, Ho WH, Maruoka M, Corpuz RT, Baldwin DT, Foster JS, Goddard AD, Yansura DG, Vandlen RL, Wood WI, Gurney AL (2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1". J. Biol. Chem. 276 (2): 1660–4. doi:10.1074/jbc.M008289200. PMID 11058597.  

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