The Full Wiki

More info on Interleukin-1 receptor

Interleukin-1 receptor: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

interleukin 1 receptor, type I
Identifiers
Symbol IL1R1
Alt. symbols IL1R, IL1RA
Entrez 3554
HUGO 5993
OMIM 147810
RefSeq NM_000877
UniProt P14778
Other data
Locus Chr. 2 q12
interleukin 1 receptor, type II
Identifiers
Symbol IL1R2
Alt. symbols IL1RB
Entrez 7850
HUGO 5994
OMIM 147811
RefSeq NM_173343
UniProt P27930
Other data
Locus Chr. 2 q12
interleukin 1 receptor accessory protein
Identifiers
Symbol IL1RAP
Alt. symbols IL-1RAcP, IL1R3, C3orf13
Entrez 3556
HUGO 5995
OMIM 602626
RefSeq NM_134470
UniProt Q9NPH3
Other data
Locus Chr. 3 q28

Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]

The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]

References

  1. ^ a b Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway" (abstract page). J. Leukoc. Biol. 56 (5): 542–7. PMID 7964161. http://www.jleukbio.org/cgi/content/abstract/56/5/542.  
  2. ^ Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMID 1834696.  
  3. ^ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message