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Interleukin-4 receptor: Wikis

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Interleukin 4 receptor

PDB rendering based on 1iar.
Available structures
1iar
Identifiers
Symbols IL4R; CD124; IL4RA
External IDs OMIM147781 MGI105367 HomoloGene7784 GeneCards: IL4R Gene
RNA expression pattern
PBB GE IL4R 203233 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3566 16190
Ensembl ENSG00000077238 ENSMUSG00000030748
UniProt P24394 Q3U905
RefSeq (mRNA) NM_000418 NM_001008700
RefSeq (protein) NP_000409 NP_001008700
Location (UCSC) Chr 16:
27.26 - 27.28 Mb
Chr 7:
125.36 - 125.37 Mb
PubMed search [1] [2]

Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.[1]

Contents

See also

Interactions

Interleukin-4 receptor has been shown to interact with SHC1.[2][3]

References

  1. ^ "Entrez Gene: IL4R interleukin 4 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3566.  
  2. ^ Ikizawa, K; Yanagihara Y (Feb. 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. ISSN 0006-291X. PMID 10652211.  
  3. ^ Kashiwada, M; Giallourakis C C, Pan P Y, Rothman P B (Dec. 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. (United States) 167 (11): 6382–7. ISSN 0022-1767. PMID 11714803.  

Further reading

External links

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