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Interleukin-7 receptor: Wikis


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Interleukin 7 receptor
Symbols IL7R; CD127; CDW127; IL-7R-alpha
External IDs OMIM146661 MGI96562 HomoloGene1646 GeneCards: IL7R Gene
RNA expression pattern
PBB GE IL7R 205798 at tn.png
More reference expression data
Species Human Mouse
Entrez 3575 16197
Ensembl ENSG00000168685 ENSMUSG00000003882
UniProt P16871 Q3U3Z0
RefSeq (mRNA) XM_001127146 NM_008372
RefSeq (protein) XP_001127146 NP_032398
Location (UCSC) Chr 5:
35.89 - 35.92 Mb
Chr 15:
9.45 - 9.47 Mb
PubMed search [1] [2]

Interleukin 7 receptor (IL7R) also known as CD127 (Cluster of Differentiation 127) is a type I cytokine receptor. IL7R also denotes its human gene.

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG, or CD132), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [1] It has also recently been linked to the pathogenesis of multiple sclerosis. [2]


See also


Further reading

  • Akashi K, Kondo M, Weissman IL (1999). "Role of interleukin-7 in T-cell development from hematopoietic stem cells.". Immunol. Rev. 165: 13–28. doi:10.1111/j.1600-065X.1998.tb01226.x. PMID 9850848. 
  • Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis.". Cytokines Cell. Mol. Ther. 5 (1): 25–39. PMID 10390077. 
  • Al-Rawi MA, Mansel RE, Jiang WG (2004). "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.". Histol. Histopathol. 18 (3): 911–23. PMID 12792903. 
  • Banham AH (2007). "Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells.". Trends Immunol. 27 (12): 541–4. doi:10.1016/ PMID 17045841. 
  • Nishii K, Kita K, Miwa H, et al. (1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13.". Leukemia 6 (7): 662–8. PMID 1378163. 
  • Lynch M, Baker E, Park LS, et al. (1992). "The interleukin-7 receptor gene is at 5p13.". Hum. Genet. 89 (5): 566–8. doi:10.1007/BF00219186. PMID 1634235. 
  • Pleiman CM, Gimpel SD, Park LS, et al. (1991). "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.". Mol. Cell. Biol. 11 (6): 3052–9. PMID 2038316. 
  • Goodwin RG, Friend D, Ziegler SF, et al. (1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.". Cell 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865. 
  • Seckinger P, Fougereau M (1994). "Activation of src family kinases in human pre-B cells by IL-7.". J. Immunol. 153 (1): 97–109. PMID 7515933. 
  • Noguchi M, Nakamura Y, Russell SM, et al. (1994). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.". Science 262 (5141): 1877–80. doi:10.1126/science.8266077. PMID 8266077. 
  • van der Plas DC, Smiers F, Pouwels K, et al. (1996). "Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.". Leukemia 10 (8): 1317–25. PMID 8709637. 
  • Maraskovsky E, O'Reilly LA, Teepe M, et al. (1997). "Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice.". Cell 89 (7): 1011–9. doi:10.1016/S0092-8674(00)80289-5. PMID 9215624. 
  • Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR (1998). "Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor.". Nature 391 (6670): 904–7. doi:10.1038/36122. PMID 9495344. 
  • Puel A, Ziegler SF, Buckley RH, Leonard WJ (1998). "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.". Nat. Genet. 20 (4): 394–7. doi:10.1038/3877. PMID 9843216. 
  • Ye SK, Maki K, Kitamura T, et al. (1999). "Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor.". Immunity 11 (2): 213–23. doi:10.1016/S1074-7613(00)80096-5. PMID 10485656. 
  • Benbernou N, Muegge K, Durum SK (2000). "Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha.". J. Biol. Chem. 275 (10): 7060–5. doi:10.1074/jbc.275.10.7060. PMID 10702271. 
  • Roifman CM, Zhang J, Chitayat D, Sharfe N (2000). "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency.". Blood 96 (8): 2803–7. PMID 11023514. 
  • Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.". J. Immunol. 167 (1): 336–43. PMID 11418668. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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