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Interleukin 10 receptor, alpha subunit: Wikis


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Interleukin 10 receptor, alpha

PDB rendering based on 1j7v.
Available structures
1j7v, 1lqs, 1y6k, 1y6m, 1y6n
Symbols IL10RA; CDW210A; HIL-10R; IL-10R1; IL10R
External IDs OMIM146933 MGI96538 HomoloGene1196 GeneCards: IL10RA Gene
RNA expression pattern
PBB GE IL10RA 204912 at tn.png
More reference expression data
Species Human Mouse
Entrez 3587 16154
Ensembl ENSG00000110324 ENSMUSG00000032089
UniProt Q13651 Q3U6I9
RefSeq (mRNA) NM_001558 NM_008348
RefSeq (protein) NP_001549 NP_032374
Location (UCSC) Chr 11:
117.36 - 117.38 Mb
Chr 9:
45 - 45.02 Mb
PubMed search [1] [2]

Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. IL10RA, is its human gene.

IL10RA has also recently been designated CDW210A (cluster of differentiation W210A).

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.[1]


Interleukin 10 receptor, alpha subunit has been shown to interact with Interleukin 10[2][3][4][5][6] and Janus kinase 1.[7][8]


  1. ^ "Entrez Gene: IL10RA interleukin 10 receptor, alpha".  
  2. ^ Ho, A S; Liu Y, Khan T A, Hsu D H, Bazan J F, Moore K W (Dec. 1993). "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 90 (23): 11267–71. ISSN 0027-8424. PMID 8248239.  
  3. ^ Josephson, K; Logsdon N J, Walter M R (Jul. 2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity (United States) 15 (1): 35–46. ISSN 1074-7613. PMID 11485736.  
  4. ^ Tan, J C; Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, Narula S K, Zavodny P J, Chou C C (May. 1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. (UNITED STATES) 270 (21): 12906–11. ISSN 0021-9258. PMID 7759550.  
  5. ^ Josephson, K; McPherson D T, Walter M R (Dec. 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D Biol. Crystallogr. (Denmark) 57 (Pt 12): 1908–11. ISSN 0907-4449. PMID 11717514.  
  6. ^ Hoover, D M; Schalk-Hihi C, Chou C C, Menon S, Wlodawer A, Zdanov A (May. 1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. (GERMANY) 262 (1): 134–41. ISSN 0014-2956. PMID 10231374.  
  7. ^ Usacheva, Anna; Sandoval Raudel, Domanski Paul, Kotenko Sergei V, Nelms Keats, Goldsmith Mark A, Colamonici Oscar R (Dec. 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation". J. Biol. Chem. (United States) 277 (50): 48220–6. doi:10.1074/jbc.M205757200. ISSN 0021-9258. PMID 12374810.  
  8. ^ Usacheva, Anna; Kotenko Sergei, Witte Michael M, Colamonici Oscar R (Aug. 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. (United States) 169 (3): 1302–8. ISSN 0022-1767. PMID 12133952.  

Further reading

  • Donnelly RP, Dickensheets H, Finbloom DS (1999). "The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes.". J. Interferon Cytokine Res. 19 (6): 563–73. doi:10.1089/107999099313695. PMID 10433356.  
  • Carson WE, Lindemann MJ, Baiocchi R, et al. (1995). "The functional characterization of interleukin-10 receptor expression on human natural killer cells.". Blood 85 (12): 3577–85. PMID 7540068.  
  • Ho AS, Wei SH, Mui AL, et al. (1995). "Functional regions of the mouse interleukin-10 receptor cytoplasmic domain.". Mol. Cell. Biol. 15 (9): 5043–53. PMID 7544437.  
  • Tan JC, Braun S, Rong H, et al. (1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor.". J. Biol. Chem. 270 (21): 12906–11. doi:10.1074/jbc.270.21.12906. PMID 7759550.  
  • Taniyama T, Takai S, Miyazaki E, et al. (1995). "The human interleukin-10 receptor gene maps to chromosome 11q23.3.". Hum. Genet. 95 (1): 99–101. doi:10.1007/BF00225083. PMID 7814035.  
  • Liu Y, Wei SH, Ho AS, et al. (1994). "Expression cloning and characterization of a human IL-10 receptor.". J. Immunol. 152 (4): 1821–9. PMID 8120391.  
  • Ho AS, Liu Y, Khan TA, et al. (1994). "A receptor for interleukin 10 is related to interferon receptors.". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11267–71. doi:10.1073/pnas.90.23.11267. PMID 8248239.  
  • Tan JC, Indelicato SR, Narula SK, et al. (1993). "Characterization of interleukin-10 receptors on human and mouse cells.". J. Biol. Chem. 268 (28): 21053–9. PMID 8407942.  
  • Lai CF, Ripperger J, Morella KK, et al. (1996). "Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements.". J. Biol. Chem. 271 (24): 13968–75. doi:10.1074/jbc.271.24.13968. PMID 8662928.  
  • Zdanov A, Schalk-Hihi C, Wlodawer A (1997). "Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor.". Protein Sci. 5 (10): 1955–62. doi:10.1002/pro.5560051001. PMID 8897595.  
  • Kotenko SV, Krause CD, Izotova LS, et al. (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex.". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMID 9312047.  
  • Hoover DM, Schalk-Hihi C, Chou CC, et al. (1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization.". Eur. J. Biochem. 262 (1): 134–41. doi:10.1046/j.1432-1327.1999.00363.x. PMID 10231374.  
  • Müschen A, Mirmohammadsadegh A, Jarzebska-Deussen B, et al. (1999). "Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes.". Inflamm. Res. 48 (10): 539–43. doi:10.1007/s000110050500. PMID 10563471.  
  • Corinti S, Albanesi C, la Sala A, et al. (2001). "Regulatory activity of autocrine IL-10 on dendritic cell functions.". J. Immunol. 166 (7): 4312–8. PMID 11254683.  
  • Josephson K, Logsdon NJ, Walter MR (2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.". Immunity 15 (1): 35–46. doi:10.1016/S1074-7613(01)00169-8. PMID 11485736.  
  • Crepaldi L, Gasperini S, Lapinet JA, et al. (2001). "Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10.". J. Immunol. 167 (4): 2312–22. PMID 11490020.  
  • Zhou JH, Broussard SR, Strle K, et al. (2001). "IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase.". J. Immunol. 167 (8): 4436–42. PMID 11591769.  
  • Josephson K, McPherson DT, Walter MR (2002). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1.". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 12): 1908–11. doi:10.1107/S0907444901016249. PMID 11717514.  
  • Wolk K, Kunz S, Asadullah K, Sabat R (2002). "Cutting edge: immune cells as sources and targets of the IL-10 family members?". J. Immunol. 168 (11): 5397–402. PMID 12023331.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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