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Interleukin 1 receptor, type II
Symbols IL1R2; CD121b; IL1RB; MGC47725
External IDs OMIM147811 MGI96546 HomoloGene7783 GeneCards: IL1R2 Gene
RNA expression pattern
PBB GE IL1R2 205403 at tn.png
PBB GE IL1R2 211372 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7850 16178
Ensembl ENSG00000115590 ENSMUSG00000026073
UniProt P27930 Q4FK69
RefSeq (mRNA) NM_004633 NM_010555
RefSeq (protein) NP_004624 NP_034685
Location (UCSC) Chr 2:
101.97 - 102.01 Mb
Chr 1:
40.03 - 40.07 Mb
PubMed search [1] [2]

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.[1]


See also


Further reading

  • McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.". Embo J. 10 (10): 2821–32. PMID 1833184.  
  • Dripps DJ, Verderber E, Ng RK, et al. (1991). "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils.". J. Biol. Chem. 266 (30): 20311–5. PMID 1834644.  
  • Fasano MB, Cousart S, Neal S, McCall CE (1991). "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome.". J. Clin. Invest. 88 (5): 1452–9. doi:10.1172/JCI115454. PMID 1834697.  
  • Sadouk MB, Pelletier JP, Tardif G, et al. (1995). "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor.". Lab. Invest. 73 (3): 347–55. PMID 7564267.  
  • Symons JA, Young PR, Duff GW (1995). "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1714–8. doi:10.1073/pnas.92.5.1714. PMID 7878046.  
  • Arend WP, Malyak M, Smith MF, et al. (1994). "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.". J. Immunol. 153 (10): 4766–74. PMID 7963543.  
  • Giri JG, Wells J, Dower SK, et al. (1995). "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.". J. Immunol. 153 (12): 5802–9. PMID 7989776.  
  • Re F, Muzio M, De Rossi M, et al. (1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor.". J. Exp. Med. 179 (2): 739–43. doi:10.1084/jem.179.2.739. PMID 8294881.  
  • Colotta F, Re F, Muzio M, et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.". Science 261 (5120): 472–5. doi:10.1126/science.8332913. PMID 8332913.  
  • Sambo P, Fadlon EJ, Sironi M, et al. (1996). "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells.". Blood 87 (5): 1682–6. PMID 8634411.  
  • Larregina A, Morelli A, Kolkowski E, Fainboim L (1996). "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture.". Immunology 87 (2): 317–25. doi:10.1046/j.1365-2567.1996.451513.x. PMID 8698397.  
  • Liu C, Hart RP, Liu XJ, et al. (1996). "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA.". J. Biol. Chem. 271 (34): 20965–72. doi:10.1074/jbc.271.34.20965. PMID 8702856.  
  • Colotta F, Saccani S, Giri JG, et al. (1996). "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes.". J. Immunol. 156 (7): 2534–41. PMID 8786316.  
  • Sébire G, Delfraissy JF, Demotes-Mainard J, et al. (1997). "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells.". Cytokine 8 (8): 636–41. doi:10.1006/cyto.1996.0085. PMID 8894439.  
  • Lovenberg TW, Crowe PD, Liu C, et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2).". J. Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.  
  • van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF (1997). "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13.". J. Infect. Dis. 175 (1): 118–22. PMID 8985204.  
  • Rauschmayr T, Groves RW, Kupper TS (1997). "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5814–9. doi:10.1073/pnas.94.11.5814. PMID 9159157.  
  • Gomez E, Morel G, Cavalier A, et al. (1997). "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes.". Biol. Reprod. 56 (6): 1513–26. doi:10.1095/biolreprod56.6.1513. PMID 9166705.  
  • Cannon JG, Angel JB, Abad LW, et al. (1997). "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.". J. Clin. Immunol. 17 (3): 253–61. doi:10.1023/A:1027314713231. PMID 9168406.  
  • Fink GW, Norman JG (1998). "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis.". Cytokine 9 (12): 1023–7. doi:10.1006/cyto.1997.0260. PMID 9417814.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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