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Interleukin 3 (colony-stimulating factor, multiple)
Identifiers
Symbols IL3; IL-3; MCGF; MGC79398; MGC79399; MULTI-CSF
External IDs OMIM147740 HomoloGene47938 GeneCards: IL3 Gene
RNA expression pattern
PBB GE IL3 207906 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3562 16187
Ensembl ENSG00000164399 ENSMUSG00000018914
UniProt P08700 P01586
RefSeq (mRNA) NM_000588 NM_010556
RefSeq (protein) NP_000579 NP_034686
Location (UCSC) Chr 5:
131.42 - 131.43 Mb
Chr 11:
54.08 - 54.08 Mb
PubMed search [1] [2]

Interleukin 3 (colony-stimulating factor, multiple), also known as IL3, is a protein which in humans is encoded by the IL3 gene.[1][2]

Contents

Function

Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the Interleukin-3 receptor.

IL-3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells (as opposed to lymphoid progenitor cells where differentiation is stimulated by IL-7) as well as stimulates proliferation of all cells in the myeloid lineage (erythrocytes, thrombocytes, granulocytes, monocytes, and dendritic cells). It is secreted by activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.

Discovery

Interleukin-3 originally was discovered by JN Ihle in mice. He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3.[3][4]

Interactions

Interleukin 3 has been shown to interact with IL3RA.[5][6]

References

  1. ^ "Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3562.  
  2. ^ Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG (October 1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3". Cell 47 (1): 3–10. doi:10.1016/0092-8674(86)90360-0. PMID 3489530.  
  3. ^ Ihle JN, Pepersack L, Rebar L (June 1981). "Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine". J. Immunol. 126 (6): 2184–9. PMID 6971890. http://www.jimmunol.org/cgi/content/abstract/126/6/2184.  
  4. ^ Ihle JN, Weinstein Y, Keller J, Henderson L, Palaszynski E (1985). "Interleukin 3". Meth. Enzymol. 116: 540–52. doi:10.1016/S0076-6879(85)16042-8. PMID 3003517.  
  5. ^ Stomski, F C; Sun Q, Bagley C J, Woodcock J, Goodall G, Andrews R K, Berndt M C, Lopez A F (Jun. 1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. (UNITED STATES) 16 (6): 3035–46. ISSN 0270-7306. PMID 8649415.  
  6. ^ Woodcock, J M; Zacharakis B, Plaetinck G, Bagley C J, Qiyu S, Hercus T R, Tavernier J, Lopez A F (Nov. 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. (ENGLAND) 13 (21): 5176–85. ISSN 0261-4189. PMID 7957082.  

Further reading

  • Wagemaker G, Burger H, van Gils FC, et al. (1991). "Interleukin-3.". Biotherapy (Dordrecht, Netherlands) 2 (4): 337–45. PMID 2268499.  
  • Martinez-Moczygemba M, Huston DP (2003). "Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF.". J. Allergy Clin. Immunol. 112 (4): 653–65; quiz 666. doi:10.1016/S0091 (inactive 2008-06-23). PMID 14564341.  
  • Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers.". Clin. Chem. Lab. Med. 42 (12): 1347–54. doi:10.1515/CCLM.2004.253. PMID 15576295.  
  • Kitamura T, Sato N, Arai K, Miyajima A (1991). "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors.". Cell 66 (6): 1165–74. doi:10.1016/0092-8674(91)90039-2. PMID 1833064.  
  • Urdal DL, Price V, Sassenfeld HM, et al. (1989). "Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3.". Ann. N. Y. Acad. Sci. 554: 167–76. doi:10.1111/j.1749-6632.1989.tb22418.x. PMID 2544122.  
  • Otsuka T, Miyajima A, Brown N, et al. (1988). "Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones.". J. Immunol. 140 (7): 2288–95. PMID 3127463.  
  • Yang YC, Ciarletta AB, Temple PA, et al. (1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.". Cell 47 (1): 3–10. doi:10.1016/0092-8674(86)90360-0. PMID 3489530.  
  • Le Beau MM, Epstein ND, O'Brien SJ, et al. (1987). "The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q.". Proc. Natl. Acad. Sci. U.S.A. 84 (16): 5913–7. doi:10.1073/pnas.84.16.5913. PMID 3497400.  
  • Dorssers L, Burger H, Bot F, et al. (1987). "Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3.". Gene 55 (1): 115–24. doi:10.1016/0378-1119(87)90254-X. PMID 3497843.  
  • Chirmule N, Goonewardena H, Pahwa S, et al. (1995). "HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.". J. Biol. Chem. 270 (33): 19364–9. doi:10.1074/jbc.270.33.19364. PMID 7642615.  
  • Than S, Oyaizu N, Pahwa RN, et al. (1994). "Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells.". Blood 84 (1): 184–8. PMID 8018916.  
  • Le Beau MM, Espinosa R, Neuman WL, et al. (1993). "Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5484–8. doi:10.1073/pnas.90.12.5484. PMID 8516290.  
  • Stomski FC, Sun Q, Bagley CJ, et al. (1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding.". Mol. Cell. Biol. 16 (6): 3035–46. PMID 8649415.  
  • Feng Y, Klein BK, McWherter CA (1996). "Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3.". J. Mol. Biol. 259 (3): 524–41. doi:10.1006/jmbi.1996.0337. PMID 8676386.  
  • Vanhaesebroeck B, Welham MJ, Kotani K, et al. (1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMID 9113989.  
  • Klein BK, Feng Y, McWherter CA, et al. (1997). "The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling.". J. Biol. Chem. 272 (36): 22630–41. doi:10.1074/jbc.272.36.22630. PMID 9278420.  
  • Sanchez X, Suetomi K, Cousins-Hodges B, et al. (1998). "CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2.". J. Immunol. 160 (2): 906–10. PMID 9551928.  
  • Tabira T, Chui DH, Fan JP, et al. (1998). "Interleukin-3 and interleukin-3 receptors in the brain.". Ann. N. Y. Acad. Sci. 840: 107–16. doi:10.1111/j.1749-6632.1998.tb09554.x. PMID 9629242.  
  • Nilsen EM, Johansen FE, Jahnsen FL, et al. (1998). "Cytokine profiles of cultured microvascular endothelial cells from the human intestine.". Gut 42 (5): 635–42. PMID 9659156.  
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