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Iodocyanopindolol: Wikis

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1 : 1 mixture (racemate)
Systematic (IUPAC) name
(RS)-4-[2-hydroxy-3-(isopropylamino)propoxy]-3-iodo-1 H-indole-2-carbonitrile
Identifiers
CAS number 83498-72-0
ATC code none
PubChem 68618
Chemical data
Formula C 15H18IN3O2  
Mol. mass 399.227 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Iodocyanopindolol (INN) is a drug related to pindolol which acts as both a β1 adrenoreceptor antagonist and a 5-HT1A receptor antagonist. Its 125I radiolabelled derivative has been widely used in mapping the distribution of beta adrenoreceptors in the body.[1]

References

  1. ^ Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC. Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding. Circulation Research. 1983 Dec;53(6):752-8. PMID 6139182
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