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Ipratropium/salbutamol: Wikis


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Combination of
Ipratropium Muscarinic antagonist
Salbutamol Short-acting β2-adrenergic agonist
CAS number  ?
ATC code R03AK04
PubChem  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Inhalation

The combination preparation ipratropium/salbutamol is a formulation containing ipratropium bromide and salbutamol sulfate (albuterol sulfate) used in the management of chronic obstructive pulmonary disease (COPD) and asthma. It is marketed by Boehringer Ingelheim as metered dose inhaler (MDI) and nebuliser preparations under the trade name Combivent. Besides, it is marketed by Dey, L.P. (Napa, California) under the brand name DuoNeb as a nebulizer.

Since Combivent contains a chlorofluorocarbon based propellant, it is being phased out in European Union countries.

DuoNeb controversy

DuoNeb has been a subject of recent Medicare and U.S. Food and Drug Administration (FDA) controversy. FDA has moved for regulation of generic competition to commercial product whereas Medicare has moved to limit reimbursement of commercial product. Dispute resolution will have a material economic impact on leading respiratory service providers.

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