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Iproclozide
Systematic (IUPAC) name
2-(4-chlorophenoxy)-N'-isopropyl-acetohydrazide
Identifiers
CAS number 3544-35-2
ATC code N06AF06
PubChem 19063
ChemSpider 17998
Chemical data
Formula C11H15ClN2O2 
Mol. mass 242.70 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Iproclozide (trade names Sursum, Sinderesin) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant, but has since been discontinued.[1] It has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.[2][3]

See also

References

  1. ^ Suerinck A, Suerinck E. (1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". J Med Lyon. 47 (96): 573–586. PMID 5930723. 
  2. ^ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction.". Gastroenterology. 75 (3): 492–496. PMID 680506. 
  3. ^ Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0824708113, 9780824708115. 







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