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Iproniazid
Systematic (IUPAC) name
N'-isopropylisonicotinohydrazide
Identifiers
CAS number 54-92-2
ATC code N06AF05
PubChem 3748
Chemical data
Formula C 9H13N3O 
Mol. mass 179.219
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
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Iproniazid (Euphozid, Iprazid, Ipronid, Ipronin, Marsilid, Rivivol) is a hydrazine drug used as an antidepressant.[1] It acts as an irreversible and nonselective monoamine oxidase inhibitor (MAOI).[2] Though it has been widely discontinued in most of the world, it is still used in France.

History

Iproniazid was the first antidepressant ever marketed. It was originally intended for the treatment of tuberculosis.[1] In 1952, its antidepressant properties were discovered when researchers noted that the patients given iproniazid became "inappropriately happy".[1] It was subsequently developed as an antidepressant and was approved for use in 1958.[1] It was later withdrawn in 1961 due to the unacceptable incidence of hepatitis and was replaced by less hepatotoxic drugs like isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).[1]

Iproniazid was developed using the same hydrazine that was used to power German V-2 rockets.[3]

See also

References

  1. ^ a b c d e Robert A. Maxwell, Shohreh B. Eckhardt (1990). Drug discovery. Humana Press. p. 455. ISBN 0896031802, 9780896031807.  
  2. ^ Fagervall I, Ross SB (April 1986). "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors". Biochemical pharmacology 35 (8): 1381–7. PMID 2870717. http://linkinghub.elsevier.com/retrieve/pii/0006-2952(86)90285-6.  
  3. ^ López-Muñoz, F; Alamo (2009). "Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today". Current pharmaceutical design 15 (14): 1563–86. doi:10.2174/138161209788168001. PMID 19442174.   edit







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