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Isamoltane
Systematic (IUPAC) name
1-(propan-2-ylamino)-3-(2-pyrrol-1-ylphenoxy)propan-2-ol
Identifiers
CAS number 99740-06-4
ATC code none
PubChem 127403
Chemical data
Formula C 16H22N2O2  
Mol. mass 274.357 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Isamoltane (CGP 361A) is a phenoxypropanolamine derivative drug and research chemical used in scientific studies. It is purported to have anxiolytic properties.[1] It acts as an antagonist at the β-adrenergic, 5-HT1A, and 5-HT1B receptors. It has about five times the potency for the 5-HT1B receptor (21 nmol/l) over the 5-HT1A receptor (112 nmol/l).[2]

References

  1. ^ Waldmeier PC, Williams M, Baumann PA, Bischoff S, Sills MA, Neale RF. (1988). "Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.". Naunyn Schmiedebergs Arch Pharmacol. 337 (6): 609–620. PMID 2905765.  
  2. ^ Rényi L, Larsson LG, Berg S, Svensson BE, Thorell G, Ross SB. (1991). "Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain.". Naunyn Schmiedebergs Arch Pharmacol. 343 (1): 1–6. PMID 1674359.  
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