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Isoxsuprine: Wikis

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Isoxsuprine[1]
Identifiers
CAS number 395-28-8
PubChem 3783
MeSH Isoxsuprine
SMILES
Properties
Molecular formula C18H23NO3
Molar mass 301.38 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Isoxsuprine, or Isoxsuprine hydrochloride, is a drug used as a vasodilator[2] in humans and equines.

Contents

Use in equines

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Reasons for use and controversy

Isoxsuprine is most commonly used to treat hoof-related problems in the horse, most commonly for laminitis and navicular disease, as its effects as a vasodilator are thought to increase circulation within the hoof to help counteract the problems associated with these conditions.

There are many veterinarians—and horsemen—who do not believe isoxsuprine to be effective. Its use is therefore rather controversial within the veterinary field.

Precautions and side-effects

Isoxsuprine may increase the animal's heart rate, cause changes in blood pressure, and irritate the GI tract. It should therefore be used with caution if combined with other drugs that affect blood pressure, such as sedatives and anesthetic drugs. Because it is a vasodilator, it should not be used in horses that are bleeding, or in mares following foaling.

Isoxsuprine is a prohibited class B drug in FEI-regulated competition, and is often prohibited by other equine associations. It may be detected in the urine for several weeks or months following administration. It is therefore important to check the drug-rules within an animal's given competitive organization, before administering the drug.

Administration

Isoxsurpine is given orally, and many horses find the pills quite palatable.

Uses and Mechanism of use in humans

Isoxsuprine is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Therefore, it's used in humans for treatment of premature labour.

References

Sources

Forney, Barbara C, MS, VMD.Equine Medications, Revised Edition. Blood Horse Publications. Lexington, KY. Copyright 2007.


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