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Jumonji, AT rich interactive domain 1A
Identifiers
Symbols JARID1A; RBBP2; RBP2
External IDs OMIM180202 MGI2136980 HomoloGene3419 GeneCards: JARID1A Gene
RNA expression pattern
PBB GE JARID1A 215698 at tn.png
PBB GE JARID1A 202040 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5927 214899
Ensembl ENSG00000073614 ENSMUSG00000030180
UniProt P29375 n/a
RefSeq (mRNA) NM_001042603 XM_359326
RefSeq (protein) NP_001036068 XP_359326
Location (UCSC) Chr 12:
0.26 - 0.37 Mb
Chr 6:
120.33 - 120.4 Mb
PubMed search [1] [2]

Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.[1][2]

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. It was formally known as Retinoblastoma Binding Protein 2 (RBP2). This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

This protein was found to be an H3K4 histone demethylase that binds to c-Myc. [3] It was recently renamed to Lysine Demethylase 5A (KDM5A).

Contents

Interactions

JARID1A has been shown to interact with Estrogen receptor alpha,[4] LMO2[5] and Retinoblastoma protein.[4][6]

References

  1. ^ Defeo-Jones D, Huang PS, Jones RE, Haskell KM, Vuocolo GA, Hanobik MG, Huber HE, Oliff A (Aug 1991). "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product". Nature 352 (6332): 251–4. doi:10.1038/352251a0. PMID 1857421.  
  2. ^ a b "Entrez Gene: JARID1A jumonji, AT rich interactive domain 1A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5927.  
  3. ^ Secombe J, Li L, Carlos L, Eisenman RN (2007). "The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth". Genes Dev. 21 (5): 537–51. doi:10.1101/gad.1523007. PMID 17311883.  
  4. ^ a b Chan, S W; Hong W (Jul. 2001). "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription". J. Biol. Chem. (United States) 276 (30): 28402–12. doi:10.1074/jbc.M100313200. ISSN 0021-9258. PMID 11358960.  
  5. ^ Mao, S; Neale G A, Goorha R M (Apr. 1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene (ENGLAND) 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. ISSN 0950-9232. PMID 9129143.  
  6. ^ Kim, Y W; Otterson G A, Kratzke R A, Coxon A B, Kaye F J (Nov. 1994). "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Mol. Cell. Biol. (UNITED STATES) 14 (11): 7256–64. ISSN 0270-7306. PMID 7935440.  

Further reading

  • Kim YW, Otterson GA, Kratzke RA, et al. (1994). "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.". Mol. Cell. Biol. 14 (11): 7256–64. PMID 7935440.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Fattaey AR, Helin K, Dembski MS, et al. (1993). "Characterization of the retinoblastoma binding proteins RBP1 and RBP2.". Oncogene 8 (11): 3149–56. PMID 8414517.  
  • Baens M, Aerssens J, van Zand K, et al. (1996). "Isolation and regional assignment of human chromosome 12p cDNAs.". Genomics 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Mao S, Neale GA, Goorha RM (1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2.". Oncogene 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. PMID 9129143.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Chan SW, Hong W (2001). "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription.". J. Biol. Chem. 276 (30): 28402–12. doi:10.1074/jbc.M100313200. PMID 11358960.  
  • Sandrock B, Egly JM (2001). "A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH.". J. Biol. Chem. 276 (38): 35328–33. doi:10.1074/jbc.M105570200. PMID 11445587.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Benevolenskaya EV, Murray HL, Branton P, et al. (2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.". Mol. Cell 18 (6): 623–35. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Tzschach A, Lenzner S, Moser B, et al. (2006). "Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.". Hum. Mutat. 27 (4): 389. doi:10.1002/humu.9420. PMID 16541399.  
  • Roesch A, Becker B, Schneider-Brachert W, et al. (2006). "Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.". J. Invest. Dermatol. 126 (8): 1850–9. doi:10.1038/sj.jid.5700324. PMID 16645588.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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