The Full Wiki

More info on JARID1B

JARID1B: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Jumonji, AT rich interactive domain 1B
Symbols JARID1B; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; PLU-1; PUT1; RBBP2H1A
External IDs OMIM605393 MGI1922855 HomoloGene48448 GeneCards: JARID1B Gene
RNA expression pattern
PBB GE JARID1B 201548 s at tn.png
PBB GE JARID1B 201547 at tn.png
PBB GE JARID1B 201549 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10765 75605
Ensembl ENSG00000117139 ENSMUSG00000042207
UniProt n/a n/a
RefSeq (mRNA) NM_006618 NM_152895
RefSeq (protein) NP_006609 NP_690855
Location (UCSC) Chr 1:
200.96 - 201.05 Mb
Chr 1:
136.38 - 136.45 Mb
PubMed search [1] [2]

Lysine-specific demethylase 5B is an enzyme that in humans is encoded by the KDM5B gene.[1][2][3]



JARID1B has been shown to interact with FOXG1[4] and PAX9.[4]


  1. ^ Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (Aug 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs". Genome Res 11 (8): 1327–34. doi:10.1101/gr.168801. PMID 11483573.  
  2. ^ Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y (Jul 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry 40 (31): 9142–50. PMID 11478881.  
  3. ^ "Entrez Gene: JARID1B jumonji, AT rich interactive domain 1B".  
  4. ^ a b Tan, Keith; Shaw Anthony L, Madsen Bente, Jensen Kirsten, Taylor-Papadimitriou Joyce, Freemont Paul S (Jun. 2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9". J. Biol. Chem. (United States) 278 (23): 20507–13. doi:10.1074/jbc.M301994200. ISSN 0021-9258. PMID 12657635.  

Further reading

  • Lu PJ, Sundquist K, Baeckstrom D, et al. (1999). "A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.". J. Biol. Chem. 274 (22): 15633–45. doi:10.1074/jbc.274.22.15633. PMID 10336460.  
  • Kashuba V, Protopopov A, Podowski R, et al. (2000). "Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A).". Eur. J. Hum. Genet. 8 (6): 407–13. doi:10.1038/sj.ejhg.5200474. PMID 10878660.  
  • Barrett A, Madsen B, Copier J, et al. (2002). "PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?". Int. J. Cancer 101 (6): 581–8. doi:10.1002/ijc.10644. PMID 12237901.  
  • Tan K, Shaw AL, Madsen B, et al. (2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.". J. Biol. Chem. 278 (23): 20507–13. doi:10.1074/jbc.M301994200. PMID 12657635.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins.". Nucleic Acids Res. 33 (1): 66–80. doi:10.1093/nar/gki145. PMID 15640446.  
  • Tzschach A, Lenzner S, Moser B, et al. (2006). "Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.". Hum. Mutat. 27 (4): 389. doi:10.1002/humu.9420. PMID 16541399.  
  • Yamane K, Tateishi K, Klose RJ, et al. (2007). "PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.". Mol. Cell 25 (6): 801–12. doi:10.1016/j.molcel.2007.03.001. PMID 17363312.  
  • Barrett A, Santangelo S, Tan K, et al. (2007). "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases.". Int. J. Cancer 121 (2): 265–75. doi:10.1002/ijc.22673. PMID 17373667.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address