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Jumonji, AT rich interactive domain 1D
Symbols JARID1D; HY; HYA; KIAA0234; SMCY
External IDs OMIM426000 MGI99780 HomoloGene55838 GeneCards: JARID1D Gene
RNA expression pattern
PBB GE JARID1D 206700 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8284 20592
Ensembl ENSG00000012817 ENSMUSG00000056673
UniProt Q9BY66 Q3URX5
RefSeq (mRNA) NM_004653 XM_987789
RefSeq (protein) NP_004644 XP_992883
Location (UCSC) Chr Y:
20.33 - 20.37 Mb
Chr Y:
0.23 - 0.28 Mb
PubMed search [1] [2]

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene.[1][2][3]

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.[3]


  1. ^ Froggatt P (Feb 1977). "The foundation of the "Inst" medical department and its association with the Belfast Fever Hospital". Ulster Med J 45 (2): 107-45. PMID 795123.  
  2. ^ Kent-First MG, Maffitt M, Muallem A, Brisco P, Shultz J, Ekenberg S, Agulnik AI, Agulnik I, Shramm D, Bavister B, Abdul-Mawgood A, VandeBerg J (Nov 1996). "Gene sequence and evolutionary conservation of human SMCY". Nat Genet 14 (2): 128-9. doi:10.1038/ng1096-128. PMID 8841177.  
  3. ^ a b "Entrez Gene: JARID1D jumonji, AT rich interactive domain 1D".  

Further reading

  • Simpson E, Scott D, Chandler P (1997). "The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning.". Annu. Rev. Immunol. 15: 39–61. doi:10.1146/annurev.immunol.15.1.39. PMID 9143681.  
  • Wolf U (1998). "The serologically detected H-Y antigen revisited.". Cytogenet. Cell Genet. 80 (1-4): 232–5. doi:10.1159/000014986. PMID 9678364.  
  • Agulnik AI, Mitchell MJ, Lerner JL, et al. (1994). "A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.". Hum. Mol. Genet. 3 (6): 873–8. doi:10.1093/hmg/3.6.873. PMID 7524912.  
  • Wang W, Meadows LR, den Haan JM, et al. (1995). "Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein.". Science 269 (5230): 1588–90. doi:10.1126/science.7667640. PMID 7667640.  
  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.  
  • Agulnik AI, Bishop CE, Lerner JL, et al. (1997). "Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.". Mamm. Genome 8 (2): 134–8. doi:10.1007/s003359900372. PMID 9060413.  
  • Rufer N, Wolpert E, Helg C, et al. (1998). "HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation.". Transplantation 66 (7): 910–6. doi:10.1097/00007890-199810150-00016. PMID 9798702.  
  • Lau YF, Zhang J (2000). "Expression analysis of thirty one Y chromosome genes in human prostate cancer.". Mol. Carcinog. 27 (4): 308–21. doi:10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R. PMID 10747295.  
  • Shen P, Wang F, Underhill PA, et al. (2000). "Population genetic implications from sequence variation in four Y chromosome genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7354–9. doi:10.1073/pnas.97.13.7354. PMID 10861003.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.  
  • Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Miklos DB, Kim HT, Miller KH, et al. (2005). "Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission.". Blood 105 (7): 2973–8. doi:10.1182/blood-2004-09-3660. PMID 15613541.  
  • Piper KP, McLarnon A, Arrazi J, et al. (2007). "Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus.". Biol. Reprod. 76 (1): 96–101. doi:10.1095/biolreprod.106.055426. PMID 16988213.  
  • Iwase S, Lan F, Bayliss P, et al. (2007). "The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.". Cell 128 (6): 1077–88. doi:10.1016/j.cell.2007.02.017. PMID 17320160.  
  • Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein.". Cell 128 (5): 877–87. doi:10.1016/j.cell.2007.02.004. PMID 17320162.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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