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Jumonji, AT rich interactive domain 2
Identifiers
Symbols JARID2; JMJ
External IDs OMIM601594 MGI104813 HomoloGene31279 GeneCards: JARID2 Gene
RNA expression pattern
PBB GE JARID2 203297 s at tn.png
PBB GE JARID2 203298 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3720 16468
Ensembl ENSG00000008083 ENSMUSG00000038518
UniProt Q92833 Q1LZL9
RefSeq (mRNA) NM_004973 NM_021878
RefSeq (protein) NP_004964 NP_068678
Location (UCSC) Chr 6:
15.35 - 15.63 Mb
Chr 13:
44.83 - 44.93 Mb
PubMed search [1] [2]

Protein Jumonji is a protein that in humans is encoded by the JARID2 gene.[1][2]

This gene is an ortholog of the mouse jumonji gene, which encodes a nuclear protein essential for mouse embryogenesis, including neural tube formation. Overexpression of mouse jumonji negatively regulates cell proliferation. The jumonji proteins contain a DNA-binding domain, called an AT-rich interaction domain (ARID), and share regions of similarity with human retinoblastoma-binding protein-2 and the human SMCX protein.[2]

References

  1. ^ Berge-Lefranc JL, Jay P, Massacrier A, Cau P, Mattei MG, Bauer S, Marsollier C, Berta P, Fontes M (Feb 1997). "Characterization of the human jumonji gene". Hum Mol Genet 5 (10): 1637-41. PMID 8894700.  
  2. ^ a b "Entrez Gene: JARID2 jumonji, AT rich interactive domain 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3720.  

Further reading

  • Lee Y, Song AJ, Baker R, et al. (2000). "Jumonji, a nuclear protein that is necessary for normal heart development.". Circ. Res. 86 (9): 932–8. PMID 10807864.  
  • Toyoda M, Kojima M, Takeuchi T (2000). "Jumonji is a nuclear protein that participates in the negative regulation of cell growth.". Biochem. Biophys. Res. Commun. 274 (2): 332–6. doi:10.1006/bbrc.2000.3138. PMID 10913339.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kim TG, Kraus JC, Chen J, Lee Y (2004). "JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor.". J. Biol. Chem. 278 (43): 42247–55. doi:10.1074/jbc.M307386200. PMID 12890668.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Volcik KA, Zhu H, Finnell RH, et al. (2004). "Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects.". Am. J. Med. Genet. A 126 (2): 215–7. doi:10.1002/ajmg.a.20574. PMID 15057990.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kim TG, Chen J, Sadoshima J, Lee Y (2005). "Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.". Mol. Cell. Biol. 24 (23): 10151–60. doi:10.1128/MCB.24.23.10151-10160.2004. PMID 15542826.  
  • Pedrosa E, Ye K, Nolan KA, et al. (2007). "Positive association of schizophrenia to JARID2 gene.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (1): 45–51. doi:10.1002/ajmg.b.30386. PMID 16967465.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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