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Jun B proto-oncogene
Symbols JUNB;
External IDs OMIM165161 MGI96647 HomoloGene7390 GeneCards: JUNB Gene
RNA expression pattern
PBB GE JUNB 201473 at tn.png
More reference expression data
Species Human Mouse
Entrez 3726 16477
Ensembl ENSG00000171223 ENSMUSG00000052837
UniProt P17275 Q3TXR4
RefSeq (mRNA) NM_002229 NM_008416
RefSeq (protein) NP_002220 NP_032442
Location (UCSC) Chr 19:
12.76 - 12.77 Mb
Chr 8:
87.87 - 87.87 Mb
PubMed search [1] [2]

Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene.[1][2]



JUNB has been shown to interact with Mothers against decapentaplegic homolog 3[3] and BRCA1.[4]

See also


  1. ^ Schutte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell 59 (6): 987–97. PMID 2513129.  
  2. ^ "Entrez Gene: JUNB jun B proto-oncogene".  
  3. ^ Liberati, N T; Datto M B, Frederick J P, Shen X, Wong C, Rougier-Chapman E M, Wang X F (Apr. 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4844–9. ISSN 0027-8424. PMID 10220381.  
  4. ^ Hu, Yan-Fen; Li Rong (Jun. 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. (United States) 16 (12): 1509–17. doi:10.1101/gad.995502. ISSN 0890-9369. PMID 12080089.  

Further reading

  • Hsu JC, Bravo R, Taub R (1992). "Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration.". Mol. Cell. Biol. 12 (10): 4654–65. PMID 1406655.  
  • Zafarullah M, Martel-Pelletier J, Cloutier JM, et al. (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte.". FEBS Lett. 306 (2-3): 169–72. doi:10.1016/0014-5793(92)80992-P. PMID 1633872.  
  • Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.". Biochem. J. 273(Pt 2): 477–9. PMID 1899335.  
  • Nomura N, Ide M, Sasamoto S, et al. (1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.". Nucleic Acids Res. 18 (10): 3047–8. doi:10.1093/nar/18.10.3047. PMID 2112242.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.  
  • Phinney DG, Tseng SW, Ryder K (1996). "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci.". Genomics 28 (2): 228–34. doi:10.1006/geno.1995.1135. PMID 8530030.  
  • Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175.  
  • Neyns B, Katesuwanasing , Vermeij J, et al. (1996). "Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium.". Oncogene 12 (6): 1247–57. PMID 8649827.  
  • Mendelson KG, Contois LR, Tevosian SG, et al. (1996). "Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12908–13. doi:10.1073/pnas.93.23.12908. PMID 8917518.  
  • Aronheim A, Zandi E, Hennemann H, et al. (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.". Mol. Cell. Biol. 17 (6): 3094–102. PMID 9154808.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Fuchs SY, Xie B, Adler V, et al. (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors.". J. Biol. Chem. 272 (51): 32163–8. doi:10.1074/jbc.272.51.32163. PMID 9405416.  
  • Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.  
  • Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.". Embo J. 18 (2): 420–32. doi:10.1093/emboj/18.2.420. PMID 9889198.  
  • Liberati NT, Datto MB, Frederick JP, et al. (1999). "Smads bind directly to the Jun family of AP-1 transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMID 10220381.  
  • Chen P, Flory E, Avots A, et al. (2000). "Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors.". J. Biol. Chem. 275 (27): 20382–90. doi:10.1074/jbc.M001149200. PMID 10764760.  
  • Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos.". Oncogene 19 (14): 1752–63. doi:10.1038/sj.onc.1203491. PMID 10777209.  
  • Verrecchia F, Pessah M, Atfi A, Mauviel A (2000). "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation.". J. Biol. Chem. 275 (39): 30226–31. doi:10.1074/jbc.M005310200. PMID 10903323.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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