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Jun B proto-oncogene
Identifiers
Symbols JUNB;
External IDs OMIM165161 MGI96647 HomoloGene7390 GeneCards: JUNB Gene
RNA expression pattern
PBB GE JUNB 201473 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3726 16477
Ensembl ENSG00000171223 ENSMUSG00000052837
UniProt P17275 Q3TXR4
RefSeq (mRNA) NM_002229 NM_008416
RefSeq (protein) NP_002220 NP_032442
Location (UCSC) Chr 19:
12.76 - 12.77 Mb
Chr 8:
87.87 - 87.87 Mb
PubMed search [1] [2]

Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene.[1][2]

Contents

Interactions

JUNB has been shown to interact with Mothers against decapentaplegic homolog 3[3] and BRCA1.[4]

See also

References

  1. ^ Schutte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell 59 (6): 987–97. PMID 2513129.  
  2. ^ "Entrez Gene: JUNB jun B proto-oncogene". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=3726&rn=1.  
  3. ^ Liberati, N T; Datto M B, Frederick J P, Shen X, Wong C, Rougier-Chapman E M, Wang X F (Apr. 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4844–9. ISSN 0027-8424. PMID 10220381.  
  4. ^ Hu, Yan-Fen; Li Rong (Jun. 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. (United States) 16 (12): 1509–17. doi:10.1101/gad.995502. ISSN 0890-9369. PMID 12080089.  

Further reading

  • Hsu JC, Bravo R, Taub R (1992). "Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration.". Mol. Cell. Biol. 12 (10): 4654–65. PMID 1406655.  
  • Zafarullah M, Martel-Pelletier J, Cloutier JM, et al. (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte.". FEBS Lett. 306 (2-3): 169–72. doi:10.1016/0014-5793(92)80992-P. PMID 1633872.  
  • Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.". Biochem. J. 273(Pt 2): 477–9. PMID 1899335.  
  • Nomura N, Ide M, Sasamoto S, et al. (1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.". Nucleic Acids Res. 18 (10): 3047–8. doi:10.1093/nar/18.10.3047. PMID 2112242.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.  
  • Phinney DG, Tseng SW, Ryder K (1996). "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci.". Genomics 28 (2): 228–34. doi:10.1006/geno.1995.1135. PMID 8530030.  
  • Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175.  
  • Neyns B, Katesuwanasing , Vermeij J, et al. (1996). "Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium.". Oncogene 12 (6): 1247–57. PMID 8649827.  
  • Mendelson KG, Contois LR, Tevosian SG, et al. (1996). "Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12908–13. doi:10.1073/pnas.93.23.12908. PMID 8917518.  
  • Aronheim A, Zandi E, Hennemann H, et al. (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.". Mol. Cell. Biol. 17 (6): 3094–102. PMID 9154808.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Fuchs SY, Xie B, Adler V, et al. (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors.". J. Biol. Chem. 272 (51): 32163–8. doi:10.1074/jbc.272.51.32163. PMID 9405416.  
  • Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.  
  • Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.". Embo J. 18 (2): 420–32. doi:10.1093/emboj/18.2.420. PMID 9889198.  
  • Liberati NT, Datto MB, Frederick JP, et al. (1999). "Smads bind directly to the Jun family of AP-1 transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMID 10220381.  
  • Chen P, Flory E, Avots A, et al. (2000). "Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors.". J. Biol. Chem. 275 (27): 20382–90. doi:10.1074/jbc.M001149200. PMID 10764760.  
  • Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos.". Oncogene 19 (14): 1752–63. doi:10.1038/sj.onc.1203491. PMID 10777209.  
  • Verrecchia F, Pessah M, Atfi A, Mauviel A (2000). "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation.". J. Biol. Chem. 275 (39): 30226–31. doi:10.1074/jbc.M005310200. PMID 10903323.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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