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Jun D proto-oncogene
Symbols JUND;
External IDs OMIM165162 MGI96648 HomoloGene3910 GeneCards: JUND Gene
RNA expression pattern
PBB GE JUND 203752 s at tn.png
PBB GE JUND 203751 x at tn.png
PBB GE JUND 214326 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3727 16478
Ensembl ENSG00000130522 n/a
UniProt P17535 n/a
RefSeq (mRNA) NM_005354 NM_010592
RefSeq (protein) NP_005345 NP_034722
Location (UCSC) Chr 19:
18.25 - 18.25 Mb
PubMed search [1] [2]

Transcription factor jun-D is a protein that in humans is encoded by the JUND gene.[1][2]

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.[3]



JunD has been shown to interact with ATF3,[4] MEN1,[5] DNA damage-inducible transcript 3[6] and BRCA1.[7]

See also


  1. ^ Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (Jul 1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D". Nucleic Acids Res 18 (10): 3047–8. PMID 2112242.  
  2. ^ Berger I, Shaul Y (Jun 1991). "Structure and function of human jun-D". Oncogene 6 (4): 561–6. PMID 1903194.  
  3. ^ "Entrez Gene: JUND jun D proto-oncogene".  
  4. ^ Chu, H M; Tan Y, Kobierski L A, Balsam L B, Comb M J (Jan. 1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression". Mol. Endocrinol. (UNITED STATES) 8 (1): 59–68. ISSN 0888-8809. PMID 8152431.  
  5. ^ Agarwal, S K; Guru S C, Heppner C, Erdos M R, Collins R M, Park S Y, Saggar S, Chandrasekharappa S C, Collins F S, Spiegel A M, Marx S J, Burns A L (Jan. 1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell (UNITED STATES) 96 (1): 143–52. ISSN 0092-8674. PMID 9989505.  
  6. ^ Ubeda, M; Vallejo M, Habener J F (Nov. 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMID 10523647.  
  7. ^ Hu, Yan-Fen; Li Rong (Jun. 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. (United States) 16 (12): 1509–17. doi:10.1101/gad.995502. ISSN 0890-9369. PMID 12080089.  

Further reading

  • Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.". Biochem. J. 273(Pt 2): 477–9. PMID 1899335.  
  • Franklin CC, McCulloch AV, Kraft AS (1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.". Biochem. J. 305 ( Pt 3): 967–74. PMID 7848298.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Chu HM, Tan Y, Kobierski LA, et al. (1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression.". Mol. Endocrinol. 8 (1): 59–68. doi:10.1210/me.8.1.59. PMID 8152431.  
  • Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.  
  • Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175.  
  • Claret FX, Hibi M, Dhut S, et al. (1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.". Nature 383 (6599): 453–7. doi:10.1038/383453a0. PMID 8837781.  
  • Kallunki T, Deng T, Hibi M, Karin M (1997). "c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.". Cell 87 (5): 929–39. doi:10.1016/S0092-8674(00)81999-6. PMID 8945519.  
  • Aronheim A, Zandi E, Hennemann H, et al. (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.". Mol. Cell. Biol. 17 (6): 3094–102. PMID 9154808.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Labudova O, Krapfenbauer K, Moenkemann H, et al. (1998). "Decreased transcription factor junD in brains of patients with Down syndrome.". Neurosci. Lett. 252 (3): 159–62. doi:10.1016/S0304-3940(98)00569-2. PMID 9739985.  
  • Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.  
  • Agarwal SK, Guru SC, Heppner C, et al. (1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.". Cell 96 (1): 143–52. doi:10.1016/S0092-8674(00)80967-8. PMID 9989505.  
  • Liberati NT, Datto MB, Frederick JP, et al. (1999). "Smads bind directly to the Jun family of AP-1 transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMID 10220381.  
  • Gobl AE, Berg M, Lopez-Egido JR, et al. (1999). "Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism.". Biochim. Biophys. Acta 1447 (1): 51–6. PMID 10500243.  
  • Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.". Mol. Cell. Biol. 19 (11): 7589–99. PMID 10523647.  
  • Miyamoto NG, Medberry PS, Hesselgesser J, et al. (2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors.". J. Neuroimmunol. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367.  
  • Sharma SC, Richards JS (2000). "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation.". J. Biol. Chem. 275 (43): 33718–28. doi:10.1074/jbc.M003555200. PMID 10934195.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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