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JWH-073
Systematic (IUPAC) name
naphthalen-1-yl-(1-butylindol-3-yl)methanone
Identifiers
CAS number 208987-48-8
ATC code  ?
PubChem 10471670
Chemical data
Formula C23H21NO 
Mol. mass 327.42 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status Illegal in Latvia[1]

JWH-073 is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with affinity at this subtype approximately 5x the affinity at CB1.[2] The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.

On 20 April 2009, JWH-073 was claimed by researchers at the University of Freiburg to have been found in a "fertiliser" product called "Forest Humus", along with another synthetic cannabinoid (C8)-CP 47,497.[3] These claims were confirmed in July 2009, when tests of Spice product seized after the legal ban on JWH-018 had gone into effect in Germany, were shown to contain the unregulated compound JWH-073 instead.[4]

See also

References

  1. ^ [1]
  2. ^ Aung MM, Griffin G, Huffman JW, et al. (August 2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding". Drug Alcohol Depend 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540. http://linkinghub.elsevier.com/retrieve/pii/S0376871699001520. 
  3. ^ Forest Humus - Enthält synthetische Cannabinoide (in German)
  4. ^ Lindigkeit R, Boehme A, Eiserloh I, Luebbecke M, Wiggermann M, Ernst L, Beuerle T (July 2009). "Spice: A never ending story?". Forensic Science International. doi:10.1016/j.forsciint.2009.06.008. PMID 19589652. 
  5. ^ http://www.columbiamissourian.com/stories/2010/03/11/k2-and-marijuana-companion-under-paper/
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