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JWH-081: Wikis


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Systematic (IUPAC) name
4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone
CAS number 210179-46-7
ATC code  ?
PubChem 10547208
Chemical data
Formula C25H25NO2 
Mol. mass 371.47 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal

JWH-081 is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors.[1] It's been speculated to be one of the cannabinoids in herbal blends such as Pandora Potpourri [2], a product that is quickly replacing K2 Blends in states where JWH-018 is being banned. It is fairly selective for the CB1 subtype, with affinity at this subtype approximately 10x the affinity at CB2.[3]

See also


  1. ^ Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependance 2000; 60:133-140.
  2. ^
  3. ^ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson ALS, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorganic and Medicinal Chemistry. 2005; 13:89-112.


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