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JWH-081

Systematic (IUPAC) name
4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone
Identifiers
CAS number	210179-46-7
ATC code	?
PubChem	10547208
Chemical data
Formula	C25H25NO2
Mol. mass	371.47 g/mol
Therapeutic considerations
Pregnancy cat.	?
Legal status	Legal

JWH-081 is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors.^[1] It's been speculated to be one of the cannabinoids in herbal blends such as Pandora Potpourri ^[2], a product that is quickly replacing K2 Blends in states where JWH-018 is being banned. It is fairly selective for the CB₁ subtype, with affinity at this subtype approximately 10x the affinity at CB₂.^[3]

See also

• JWH-018
• JWH-073
• HU-210

References

1. ^ Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug and Alcohol Dependance 2000; 60:133-140.
2. ^ http://www.columbiamissourian.com/stories/2010/03/11/k2-and-marijuana-companion-under-paper/
3. ^ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson ALS, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB₁ and CB₂ receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB₂ receptor agonists. Bioorganic and Medicinal Chemistry. 2005; 13:89-112.