The Full Wiki

More info on JWH-200

JWH-200: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

JWH-200
Systematic (IUPAC) name
(1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanone
Identifiers
CAS number 103610-04-4
ATC code  ?
PubChem 10045570
Chemical data
Formula C25H24N2O2 
Mol. mass 384.469 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal

JWH-200 is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC,[1] but interestingly, its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro,[2] around 3 times that of THC but with less sedative effect,[3] most likely reflecting favourable pharmacokinetic characteristics.

References

  1. ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
  2. ^ Bell MR, D'Ambra TE, Kumar V, et al. (1991). Antinociceptive (aminoalkyl)indoles. Journal of Medicinal Chemistry. 34 (3): 1099–1110. PMID 1900533
  3. ^ Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (1992). Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057







Got something to say? Make a comment.
Your name
Your email address
Message