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JWH-200: Wikis


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Systematic (IUPAC) name
CAS number 103610-04-4
ATC code  ?
PubChem 10045570
Chemical data
Formula C25H24N2O2 
Mol. mass 384.469 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal

JWH-200 is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC,[1] but interestingly, its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro,[2] around 3 times that of THC but with less sedative effect,[3] most likely reflecting favourable pharmacokinetic characteristics.


  1. ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
  2. ^ Bell MR, D'Ambra TE, Kumar V, et al. (1991). Antinociceptive (aminoalkyl)indoles. Journal of Medicinal Chemistry. 34 (3): 1099–1110. PMID 1900533
  3. ^ Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (1992). Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057

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