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Juxtacapillary (J) receptors: Wikis


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J-receptors (juxtacapillary) are nerves innervating into the body of the lung. They are present in the alveolar interstitium and are innervated by fibers of the vagus nerve.[1] J-receptors respond to events such as pulmonary edema, pulmonary emboli, pneumonia, and barotrauma, which cause a decrease in oxygenation and thus lead to an increase in ventilation/respiration. They may be also stimulated by hyperinflation of the lung as well as intravenous or intracardiac administration of chemicals.[citation needed]

The stimulation of the J-receptors causes a reflex increase in breathing rate, and is also thought to be involved in the sensation of dyspnea, the subjective sensation of difficulty breathing.[2][3] The reflex response that is produced is apnea followed by rapid breathing, bradycardia, and hypotension (pulmonary chemoreflex). The physiologic role of this reflex is uncertain, but it probably occurs in pathologic states such as pulmonary congestion or embolization.[4]


  1. ^ Sircar, Sabyasachi. Principles of Medical Physiology. pp. 350–51. ISBN 1588905721. 
  2. ^ A.A. Majid, A.N.Kingsworth, Fundamentals of Surgical Practice. Cambridge, MA: Cambridge University Press, 2006. ISBN 0-521-67706-8.
  3. ^ J.C. Bennett, F.Plum ed. Cecil Textbook of Medicine, 20th ed., W.B. Saunders, Philadelphia PA, 1996. ISBN 0-7216-3574-1
  4. ^ Ganong WF. 2005. Chapter 36 regulation of respiration. Review of medical physiology. 22nd ed. McGraw Hill.


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