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Potassium voltage-gated channel, Isk-related family, member 4
Symbols KCNE4; MGC20353; MIRP3
External IDs OMIM607775 MGI1891125 HomoloGene10959 GeneCards: KCNE4 Gene
RNA expression pattern
PBB GE KCNE4 222379 at tn.png
More reference expression data
Species Human Mouse
Entrez 23704 57814
Ensembl ENSG00000152049 ENSMUSG00000047330
UniProt Q8WWG9 Q9WTW3
RefSeq (mRNA) NM_080671 NM_021342
RefSeq (protein) NP_542402 NP_067317
Location (UCSC) Chr 2:
223.63 - 223.63 Mb
Chr 1:
78.7 - 78.7 Mb
PubMed search [1] [2]

Potassium voltage-gated channel subfamily E member 4 is a protein that in humans is encoded by the KCNE4 gene.[1][2][3]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.[3]


See also


  1. ^ Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA (May 1999). "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia". Cell 97 (2): 175-87. PMID 10219239.  
  2. ^ Teng S, Ma L, Zhen Y, Lin C, Bahring R, Vardanyan V, Pongs O, Hui R (Apr 2003). "Novel gene hKCNE4 slows the activation of the KCNQ1 channel". Biochem Biophys Res Commun 303 (3): 808-13. PMID 12670483.  
  3. ^ a b "Entrez Gene: KCNE4 potassium voltage-gated channel, Isk-related family, member 4".  

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Grunnet M, Jespersen T, Rasmussen HB, et al. (2003). "KCNE4 is an inhibitory subunit to the KCNQ1 channel.". J. Physiol. (Lond.) 542 (Pt 1): 119–30. doi:10.1113/jphysiol.2002.017301. PMID 12096056.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Grunnet M, Rasmussen HB, Hay-Schmidt A, et al. (2004). "KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.". Biophys. J. 85 (3): 1525–37. doi:10.1016/S0006-3495(03)74585-8. PMID 12944270.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Grunnet M, Olesen SP, Klaerke DA, Jespersen T (2005). "hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.". Biochem. Biophys. Res. Commun. 328 (4): 1146–53. doi:10.1016/j.bbrc.2005.01.071. PMID 15707997.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Lundquist AL, Turner CL, Ballester LY, George AL (2006). "Expression and transcriptional control of human KCNE genes.". Genomics 87 (1): 119–28. doi:10.1016/j.ygeno.2005.09.004. PMID 16303284.  
  • Zeng Z, Tan C, Teng S, et al. (2007). "The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population.". Cardiology 108 (2): 97–103. doi:10.1159/000095943. PMID 17016049.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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