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Potassium voltage-gated channel, subfamily G, member 1
Identifiers
Symbols KCNG1; K13; KCNG; KV6.1; MGC12878; kH2
External IDs OMIM603788 MGI3616086 HomoloGene20515 IUPHAR: Kv6.1 GeneCards: KCNG1 Gene
RNA expression pattern
PBB GE KCNG1 214595 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3755 241794
Ensembl ENSG00000026559 ENSMUSG00000074575
UniProt Q9UIX4 A2BDX4
RefSeq (mRNA) NM_002237 XM_141545
RefSeq (protein) NP_002228 XP_141545
Location (UCSC) Chr 20:
49.05 - 49.07 Mb
Chr 2:
167.95 - 167.96 Mb
PubMed search [1] [2]

Potassium voltage-gated channel subfamily G member 1 is a protein that in humans is encoded by the KCNG1 gene.[1][2][3]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Alternative splicing results in at least two transcript variants encoding distinct isoforms.[3]

Contents

See also

References

  1. ^ Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y (Feb 1998). "Isolation, characterization, and mapping of two human potassium channels". Biochem Biophys Res Commun 241 (3): 675-81. doi:10.1006/bbrc.1997.7830. PMID 9434767.  
  2. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473-508. doi:10.1124/pr.57.4.10. PMID 16382104.  
  3. ^ a b "Entrez Gene: KCNG1 potassium voltage-gated channel, subfamily G, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3755.  

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Post MA, Kirsch GE, Brown AM (1997). "Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current.". FEBS Lett. 399 (1-2): 177–82. doi:10.1016/S0014-5793(96)01316-6. PMID 8980147.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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