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KCNH5: Wikis


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From Wikipedia, the free encyclopedia

Potassium voltage-gated channel, subfamily H (eag-related), member 5
Symbols KCNH5; EAG2; H-EAG2; Kv10.2
External IDs OMIM605716 MGI3584508 HomoloGene15858 IUPHAR: Kv10.2 GeneCards: KCNH5 Gene
RNA expression pattern
PBB GE KCNH5 gnf1h06293 at tn.png
PBB GE KCNH5 gnf1h08083 at tn.png
PBB GE KCNH5 gnf1h09304 at tn.png
More reference expression data
Species Human Mouse
Entrez 27133 238271
Ensembl ENSG00000140015 ENSMUSG00000034402
UniProt Q8NCM2 Q6NZH0
RefSeq (mRNA) NM_139318 NM_172805
RefSeq (protein) NP_647479 NP_766393
Location (UCSC) Chr 14:
62.24 - 62.58 Mb
Chr 12:
75.82 - 76.1 Mb
PubMed search [1] [2]

Potassium voltage-gated channel, subfamily H (eag-related), member 5, also known as KCNH5, is a human gene encoding the Kv10.2 protein. [1]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. This gene is not expressed in differentiating myoblasts. Alternative splicing results in three transcript variants encoding distinct isoforms.[1]


Further reading

  • Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.  
  • Occhiodoro T, Bernheim L, Liu JH, et al. (1998). "Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion.". FEBS Lett. 434 (1-2): 177–82. doi:10.1016/S0014-5793(98)00973-9. PMID 9738473.  
  • Volorio S, Simon G, Repetto M, et al. (1999). "Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein.". DNA Seq. 9 (5-6): 307–15. doi:10.3109/10425179809008469. PMID 10524757.  
  • Schönherr R, Gessner G, Löber K, Heinemann SH (2002). "Functional distinction of human EAG1 and EAG2 potassium channels.". FEBS Lett. 514 (2-3): 204–8. doi:10.1016/S0014-5793(02)02365-7. PMID 11943152.  
  • Ju M, Wray D (2002). "Molecular identification and characterisation of the human eag2 potassium channel.". FEBS Lett. 524 (1-3): 204–10. doi:10.1016/S0014-5793(02)03055-7. PMID 12135768.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  


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