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Kv channel interacting protein 1

PDB rendering based on 1s1e.
Available structures
1s1e, 1s6c, 2i2r, 2nz0
Identifiers
Symbols KCNIP1; KCHIP1; MGC95; VABP
External IDs OMIM604660 MGI1917607 HomoloGene22824 GeneCards: KCNIP1 Gene
RNA expression pattern
PBB GE KCNIP1 221307 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 30820 70357
Ensembl ENSG00000182132 ENSMUSG00000053519
UniProt Q9NZI2 Q3YAB4
RefSeq (mRNA) NM_001034837 NM_027398
RefSeq (protein) NP_001030009 NP_081674
Location (UCSC) Chr 5:
169.71 - 170.1 Mb
Chr 11:
33.53 - 33.89 Mb
PubMed search [1] [2]

Kv channel-interacting protein 1 is a protein that in humans is encoded by the KCNIP1 gene.[1][2]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]

Contents

References

  1. ^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature 403 (6769): 553-6. doi:10.1038/35000592. PMID 10676964.  
  2. ^ a b "Entrez Gene: KCNIP1 Kv channel interacting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30820.  

See also

Further reading

  • Bähring R, Dannenberg J, Peters HC, et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.". J. Biol. Chem. 276 (26): 23888–94. doi:10.1074/jbc.M101320200. PMID 11287421.  
  • Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2.". FEBS Lett. 499 (3): 205–9. PMID 11423117.  
  • Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome.". Nucleic Acids Res. 30 (14): 3163–70. PMID 12136098.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Shibata R, Misonou H, Campomanes CR, et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.". J. Biol. Chem. 278 (38): 36445–54. doi:10.1074/jbc.M306142200. PMID 12829703.  
  • Van Hoorick D, Raes A, Keysers W, et al. (2004). "Differential modulation of Kv4 kinetics by KCHIP1 splice variants.". Mol. Cell. Neurosci. 24 (2): 357–66. PMID 14572458.  
  • Scannevin RH, Wang K, Jow F, et al. (2004). "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.". Neuron 41 (4): 587–98. PMID 14980207.  
  • Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.". Biochem. Biophys. Res. Commun. 319 (3): 720–4. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.  
  • Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2.". Biochem. Biophys. Res. Commun. 321 (3): 606–10. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.". Genomics 86 (5): 581–93. doi:10.1016/j.ygeno.2005.07.001. PMID 16112838.  
  • Pioletti M, Findeisen F, Hura GL, Minor DL (2007). "Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer.". Nat. Struct. Mol. Biol. 13 (11): 987–95. doi:10.1038/nsmb1164. PMID 17057713.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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