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Kv channel interacting protein 1

PDB rendering based on 1s1e.
Available structures
1s1e, 1s6c, 2i2r, 2nz0
External IDs OMIM604660 MGI1917607 HomoloGene22824 GeneCards: KCNIP1 Gene
RNA expression pattern
PBB GE KCNIP1 221307 at tn.png
More reference expression data
Species Human Mouse
Entrez 30820 70357
Ensembl ENSG00000182132 ENSMUSG00000053519
UniProt Q9NZI2 Q3YAB4
RefSeq (mRNA) NM_001034837 NM_027398
RefSeq (protein) NP_001030009 NP_081674
Location (UCSC) Chr 5:
169.71 - 170.1 Mb
Chr 11:
33.53 - 33.89 Mb
PubMed search [1] [2]

Kv channel-interacting protein 1 is a protein that in humans is encoded by the KCNIP1 gene.[1][2]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]



  1. ^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature 403 (6769): 553-6. doi:10.1038/35000592. PMID 10676964.  
  2. ^ a b "Entrez Gene: KCNIP1 Kv channel interacting protein 1".  

See also

Further reading

  • Bähring R, Dannenberg J, Peters HC, et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.". J. Biol. Chem. 276 (26): 23888–94. doi:10.1074/jbc.M101320200. PMID 11287421.  
  • Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2.". FEBS Lett. 499 (3): 205–9. PMID 11423117.  
  • Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome.". Nucleic Acids Res. 30 (14): 3163–70. PMID 12136098.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Shibata R, Misonou H, Campomanes CR, et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.". J. Biol. Chem. 278 (38): 36445–54. doi:10.1074/jbc.M306142200. PMID 12829703.  
  • Van Hoorick D, Raes A, Keysers W, et al. (2004). "Differential modulation of Kv4 kinetics by KCHIP1 splice variants.". Mol. Cell. Neurosci. 24 (2): 357–66. PMID 14572458.  
  • Scannevin RH, Wang K, Jow F, et al. (2004). "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.". Neuron 41 (4): 587–98. PMID 14980207.  
  • Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.". Biochem. Biophys. Res. Commun. 319 (3): 720–4. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.  
  • Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2.". Biochem. Biophys. Res. Commun. 321 (3): 606–10. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.". Genomics 86 (5): 581–93. doi:10.1016/j.ygeno.2005.07.001. PMID 16112838.  
  • Pioletti M, Findeisen F, Hura GL, Minor DL (2007). "Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer.". Nat. Struct. Mol. Biol. 13 (11): 987–95. doi:10.1038/nsmb1164. PMID 17057713.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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