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KCNJ14: Wikis


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Potassium inwardly-rectifying channel, subfamily J, member 14
Symbols KCNJ14; IRK4; KIR2.4; MGC46111
External IDs OMIM603953 MGI2384820 HomoloGene27086 IUPHAR: Kir2.4 GeneCards: KCNJ14 Gene
RNA expression pattern
PBB GE KCNJ14 220776 at tn.png
More reference expression data
Species Human Mouse
Entrez 3770 211480
Ensembl ENSG00000182324 ENSMUSG00000058743
UniProt Q9UNX9 Q8R1Z6
RefSeq (mRNA) NM_013348 NM_145963
RefSeq (protein) NP_037480 NP_666075
Location (UCSC) Chr 19:
53.65 - 53.66 Mb
Chr 7:
45.68 - 45.69 Mb
PubMed search [1] [2]

Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as Kir2.4, is a human gene.[1]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encoding the same protein have been found for this gene.[1]


See also


Further reading

  • Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Töpert C, Döring F, Wischmeyer E, et al. (1998). "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.". J. Neurosci. 18 (11): 4096–105. PMID 9592090.  
  • Töpert C, Döring F, Derst C, et al. (2000). "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14).". Mamm. Genome 11 (3): 247–9. doi:10.1007/s003350010047. PMID 10723734.  
  • Hughes BA, Kumar G, Yuan Y, et al. (2000). "Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel.". Am. J. Physiol., Cell Physiol. 279 (3): C771–84. PMID 10942728.  
  • Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fang Y, Schram G, Romanenko VG, et al. (2005). "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.". Am. J. Physiol., Cell Physiol. 289 (5): C1134–44. doi:10.1152/ajpcell.00077.2005. PMID 15958527.  
  • Tennant BP, Cui Y, Tinker A, Clapp LH (2007). "Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits.". J. Membr. Biol. 213 (1): 19–29. doi:10.1007/s00232-006-0037-y. PMID 17347781.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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