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Potassium inwardly-rectifying channel, subfamily J, member 14
Identifiers
Symbols KCNJ14; IRK4; KIR2.4; MGC46111
External IDs OMIM603953 MGI2384820 HomoloGene27086 IUPHAR: Kir2.4 GeneCards: KCNJ14 Gene
RNA expression pattern
PBB GE KCNJ14 220776 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3770 211480
Ensembl ENSG00000182324 ENSMUSG00000058743
UniProt Q9UNX9 Q8R1Z6
RefSeq (mRNA) NM_013348 NM_145963
RefSeq (protein) NP_037480 NP_666075
Location (UCSC) Chr 19:
53.65 - 53.66 Mb
Chr 7:
45.68 - 45.69 Mb
PubMed search [1] [2]

Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as Kir2.4, is a human gene.[1]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encoding the same protein have been found for this gene.[1]

Contents

See also

References

Further reading

  • Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Töpert C, Döring F, Wischmeyer E, et al. (1998). "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.". J. Neurosci. 18 (11): 4096–105. PMID 9592090.  
  • Töpert C, Döring F, Derst C, et al. (2000). "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14).". Mamm. Genome 11 (3): 247–9. doi:10.1007/s003350010047. PMID 10723734.  
  • Hughes BA, Kumar G, Yuan Y, et al. (2000). "Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel.". Am. J. Physiol., Cell Physiol. 279 (3): C771–84. PMID 10942728.  
  • Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fang Y, Schram G, Romanenko VG, et al. (2005). "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.". Am. J. Physiol., Cell Physiol. 289 (5): C1134–44. doi:10.1152/ajpcell.00077.2005. PMID 15958527.  
  • Tennant BP, Cui Y, Tinker A, Clapp LH (2007). "Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits.". J. Membr. Biol. 213 (1): 19–29. doi:10.1007/s00232-006-0037-y. PMID 17347781.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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