The Full Wiki

More info on KCNJ15

KCNJ15: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Potassium inwardly-rectifying channel, subfamily J, member 15
Symbols KCNJ15; IRKK; KIR1.3; KIR4.2; MGC13584
External IDs OMIM602106 MGI1310000 HomoloGene1690 IUPHAR: Kir4.2 GeneCards: KCNJ15 Gene
RNA expression pattern
PBB GE KCNJ15 210119 at tn.png
PBB GE KCNJ15 211806 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3772 16516
Ensembl ENSG00000157551 ENSMUSG00000062609
UniProt Q99712 Q3TNE6
RefSeq (mRNA) NM_002243 NM_001039056
RefSeq (protein) NP_002234 NP_001034145
Location (UCSC) Chr 21:
38.55 - 38.6 Mb
Chr 16:
95.37 - 95.41 Mb
PubMed search [1] [2]

Potassium inwardly-rectifying channel, subfamily J, member 15, also known as KCNJ15 is a human gene, which encodes the Kir4.2 protein.[1]



Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir4.2 is an integral membrane protein and inward-rectifier type potassium channel. Kir4.2 has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Three transcript variants encoding the same protein have been found for this gene.[1]

The existing literature describing KCNJ15 and Kir4.2 is sparse. In spite of some initial channel nomenclature confusion, in which the gene was referred to as Kir1.3[2] the channel was first cloned from human kidney by Shuck and coworkers in 1997[3]. Shortly thereafter it was shown that mutation of an extracellular lysine residue resulted in 6-fold increase in K+ current[4]. Two years later, in 1999, voltage clamp measurements in xenopus oocytes found that intracellular acidification decreased the potassium current of Kir4.2. Also activation of protein kinase C decreased the current although in a non-reversible fashion. Furthermore it was found that coexpression with related potassium channel Kir5.1, changed these results somewhat, which the authors concluded was likely to be a result of heterodimerization[2]. Further voltage clamp investigations found the exact pH sensitivity (pKa = 7.1), open probability (high) and conductance of ~25 pS[5]. In 2007 the channel was found to interact with the Calcium-sensing receptor in human kidney, using a yeast-two-hybrid system. This co-localization was verified at the protein level using both immunofluorescence techniques and coimmunoprecipitation of Kir4.2 and the Calcium-sensing receptor[6]. Also a mutational study of Kir4.2 has demonstrated that removal of a c-terminal tyrosine increased the K+ current more than 10-fold[7]. Because the channel has a very high open probability, the authors of this last article conclude that this increase is mediated by increased trafficking of the protein to the membrane and not increased single-channel conductance. This same line of reasoning is applicable to the initial work of Derst and coworkers[4].


KCNJ15 has been shown to interact with Interleukin 16.[8]

See also


  1. ^ a b "Entrez Gene: KCNJ15 potassium inwardly-rectifying channel, subfamily J, member 15".  
  2. ^ a b Pearson WL, Dourado M, Schreiber M, Salkoff L, Nichols CG (1999). "Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver". J. Physiol. (Lond.) 514 ( Pt 3): 639–53. doi:10.1111/j.1469-7793.1999.639ad.x. PMID 9882736.  
  3. ^ Shuck ME, Piser TM, Bock JH, Slightom JL, Lee KS, Bienkowski MJ (1997). "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)". J. Biol. Chem. 272 (1): 586–93. doi:10.1074/jbc.272.1.586. PMID 8995301.  
  4. ^ a b Derst C, Wischmeyer E, Preisig-Müller R, et al. (1998). "A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels". J. Biol. Chem. 273 (37): 23884–91. doi:10.1074/jbc.273.37.23884. PMID 9727001.  
  5. ^ Pessia M, Imbrici P, D'Adamo MC, Salvatore L, Tucker SJ (2001). "Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1". J. Physiol. (Lond.) 532 (Pt 2): 359–67. doi:10.1111/j.1469-7793.2001.0359f.x. PMID 11306656.  
  6. ^ Huang C, Sindic A, Hill CE, et al. (2007). "Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function". Am. J. Physiol. Renal Physiol. 292 (3): F1073–81. doi:10.1152/ajprenal.00269.2006. PMID 17122384.  
  7. ^ Pearson WL, Skatchkov SN, Eaton MJ, Nichols CG (2006). "C-terminal determinants of Kir4.2 channel expression". J. Membr. Biol. 213 (3): 187–93. doi:10.1007/s00232-006-0058-6. PMID 17468958.  
  8. ^ Kurschner, C; Yuzaki M (Sep. 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. (UNITED STATES) 19 (18): 7770–80. PMID 10479680.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address