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Potassium inwardly-rectifying channel, subfamily J, member 6
Symbols KCNJ6; BIR1; GIRK2; KATP2; KCNJ7; KIR3.2; MGC126596; hiGIRK2
External IDs OMIM600877 MGI104781 HomoloGene1688 IUPHAR: Kir3.2 GeneCards: KCNJ6 Gene
RNA expression pattern
PBB GE KCNJ6 210454 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3763 16522
Ensembl ENSG00000157542 ENSMUSG00000043301
UniProt P48051 Q0VB45
RefSeq (mRNA) NM_002240 NM_001025584
RefSeq (protein) NP_002231 NP_001020755
Location (UCSC) Chr 21:
37.92 - 38.02 Mb
Chr 16:
94.87 - 95.11 Mb
PubMed search [1] [2]

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene.[1][2][3]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.[3]



KCNJ6 has been shown to interact with KCNJ9[4][5] and DLG1.[6]

See also


  1. ^ Sakura H, Bond C, Warren-Perry M, Horsley S, Kearney L, Tucker S, Adelman J, Turner R, Ashcroft FM (Aug 1995). "Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit". FEBS Lett 367 (2): 193–7. PMID 7796919.  
  2. ^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.  
  3. ^ a b "Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6".  
  4. ^ Jelacic, T M; Kennedy M E, Wickman K, Clapham D E (Nov. 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". J. Biol. Chem. (UNITED STATES) 275 (46): 36211–6. doi:10.1074/jbc.M007087200. ISSN 0021-9258. PMID 10956667.  
  5. ^ Lavine, Natalie; Ethier Nathalie, Oak James N, Pei Lin, Liu Fang, Trieu Phan, Rebois R Victor, Bouvier Michel, Hebert Terence E, Van Tol Hubert H M (Nov. 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. (United States) 277 (48): 46010–9. doi:10.1074/jbc.M205035200. ISSN 0021-9258. PMID 12297500.  
  6. ^ Hibino, H; Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T, Hata Y, Takai Y, Kurachi Y (Jan. 2000). "Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain". EMBO J. (ENGLAND) 19 (1): 78–83. doi:10.1093/emboj/19.1.78. ISSN 0261-4189. PMID 10619846.  

Further reading

  • Patil N, Cox DR, Bhat D, et al. (1995). "A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation.". Nat. Genet. 11 (2): 126–9. doi:10.1038/ng1095-126. PMID 7550338.  
  • Ferrer J, Nichols CG, Makhina EN, et al. (1995). "Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels.". J. Biol. Chem. 270 (44): 26086–91. doi:10.1074/jbc.270.44.26086. PMID 7592809.  
  • Tsaur ML, Menzel S, Lai FP, et al. (1995). "Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM.". Diabetes 44 (5): 592–6. doi:10.2337/diabetes.44.5.592. PMID 7729621.  
  • Lesage F, Duprat F, Fink M, et al. (1994). "Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.". FEBS Lett. 353 (1): 37–42. doi:10.1016/0014-5793(94)01007-2. PMID 7926018.  
  • Liao YJ, Jan YN, Jan LY (1996). "Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain.". J. Neurosci. 16 (22): 7137–50. PMID 8929423.  
  • Signorini S, Liao YJ, Duncan SA, et al. (1997). "Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.". Proc. Natl. Acad. Sci. U.S.A. 94 (3): 923–7. doi:10.1073/pnas.94.3.923. PMID 9023358.  
  • Ohira M, Seki N, Nagase T, et al. (1997). "Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.". Genome Res. 7 (1): 47–58. doi:10.1101/gr.7.1.47. PMID 9037601.  
  • Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels.". FEBS Lett. 405 (3): 291–8. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307.  
  • Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.". Genomics 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.  
  • Inanobe A, Horio Y, Fujita A, et al. (2000). "Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis.". J. Physiol. (Lond.) 521 Pt 1: 19–30. PMID 10562331.  
  • Hibino H, Inanobe A, Tanemoto M, et al. (2000). "Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain.". Embo J. 19 (1): 78–83. doi:10.1093/emboj/19.1.78. PMID 10619846.  
  • Schoots O, Wilson JM, Ethier N, et al. (2000). "Co-expression of human Kir3 subunits can yield channels with different functional properties.". Cell. Signal. 11 (12): 871–83. doi:10.1016/S0898-6568(99)00059-5. PMID 10659995.  
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.  
  • Jelacic TM, Kennedy ME, Wickman K, Clapham DE (2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3.". J. Biol. Chem. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667.  
  • Chen L, Kawano T, Bajic S, et al. (2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8430–5. doi:10.1073/pnas.122682899. PMID 12034888.  
  • Lavine N, Ethier N, Oak JN, et al. (2003). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.". J. Biol. Chem. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ivanina T, Rishal I, Varon D, et al. (2003). "Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel.". J. Biol. Chem. 278 (31): 29174–83. doi:10.1074/jbc.M304518200. PMID 12743112.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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