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KCNJ8: Wikis


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Potassium inwardly-rectifying channel, subfamily J, member 8
Symbols KCNJ8; KIR6.1; uKATP-1
External IDs OMIM600935 MGI1100508 HomoloGene3654 IUPHAR: Kir6.1 GeneCards: KCNJ8 Gene
RNA expression pattern
PBB GE KCNJ8 205304 s at tn.png
PBB GE KCNJ8 205303 at tn.png
More reference expression data
Species Human Mouse
Entrez 3764 16523
Ensembl ENSG00000121361 ENSMUSG00000030247
UniProt Q15842 Q3U118
RefSeq (mRNA) NM_004982 NM_008428
RefSeq (protein) NP_004973 NP_032454
Location (UCSC) Chr 12:
21.81 - 21.82 Mb
Chr 6:
142.52 - 142.53 Mb
PubMed search [1] [2]

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein.[1]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.[1]


See also


Further reading

  • Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.  
  • Inagaki N, Tsuura Y, Namba N, et al. (1995). "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart.". J. Biol. Chem. 270 (11): 5691–4. doi:10.1074/jbc.270.11.5691. PMID 7890693.  
  • Inagaki N, Inazawa J, Seino S (1996). "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8).". Genomics 30 (1): 102–4. doi:10.1006/geno.1995.0018. PMID 8595887.  
  • Suzuki M, Kotake K, Fujikura K, et al. (1998). "Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria.". Biochem. Biophys. Res. Commun. 241 (3): 693–7. doi:10.1006/bbrc.1997.7891. PMID 9434770.  
  • Erginel-Unaltuna N, Yang WP, Blanar MA (1998). "Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel.". Gene 211 (1): 71–8. doi:10.1016/S0378-1119(98)00086-9. PMID 9573340.  
  • Surah-Narwal S, Xu SZ, McHugh D, et al. (1999). "Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A.". Br. J. Pharmacol. 128 (3): 667–72. doi:10.1038/sj.bjp.0702862. PMID 10516647.  
  • Tucker SJ, Ashcroft FM (1999). "Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.". J. Biol. Chem. 274 (47): 33393–7. doi:10.1074/jbc.274.47.33393. PMID 10559219.  
  • Kono Y, Horie M, Takano M, et al. (2001). "The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A.". Pflugers Arch. 440 (5): 692–8. doi:10.1007/s004240000315. PMID 11007308.  
  • Cui Y, Giblin JP, Clapp LH, Tinker A (2001). "A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits.". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 729–34. doi:10.1073/pnas.011370498. PMID 11136227.  
  • Liu Y, Ren G, O'Rourke B, et al. (2001). "Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.". Mol. Pharmacol. 59 (2): 225–30. PMID 11160857.  
  • Giblin JP, Cui Y, Clapp LH, Tinker A (2002). "Assembly limits the pharmacological complexity of ATP-sensitive potassium channels.". J. Biol. Chem. 277 (16): 13717–23. doi:10.1074/jbc.M112209200. PMID 11825905.  
  • Vanoye CG, MacGregor GG, Dong K, et al. (2002). "The carboxyl termini of K(ATP) channels bind nucleotides.". J. Biol. Chem. 277 (26): 23260–70. doi:10.1074/jbc.M112004200. PMID 11956191.  
  • Miki T, Suzuki M, Shibasaki T, et al. (2002). "Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1.". Nat. Med. 8 (5): 466–72. doi:10.1038/nm0502-466. PMID 11984590.  
  • Nakamura K, Hirano J, Itazawa S, Kubokawa M (2002). "Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells.". Am. J. Physiol. Renal Physiol. 283 (4): F784–91. doi:10.1152/ajprenal.00023.2002. PMID 12217870.  
  • Curley M, Cairns MT, Friel AM, et al. (2003). "Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium.". Mol. Hum. Reprod. 8 (10): 941–5. doi:10.1093/molehr/8.10.941. PMID 12356945.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Singh H, Hudman D, Lawrence CL, et al. (2004). "Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes.". J. Mol. Cell. Cardiol. 35 (5): 445–59. doi:10.1016/S0022-2828(03)00041-5. PMID 12738227.  
  • Insuk SO, Chae MR, Choi JW, et al. (2003). "Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells.". Int. J. Impot. Res. 15 (4): 258–66. doi:10.1038/sj.ijir.3901013. PMID 12934053.  
  • Emanuele E, Falcone C, Carabela M, et al. (2004). "Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion.". Int. J. Mol. Med. 12 (4): 509–12. PMID 12964027.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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